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Our patient was a 76\u2010year\u2010old Japanese male on dialysis. Multiple nodules accompanied by ulcers were observed on his tongue. He had no subjective symptoms or clinical findings associated with multiple myeloma. The histopathological findings suggested amyloidosis. We suspected both systemic and localized amyloidosis and performed a comprehensive systemic examination. Since the patient had been on dialysis for only a short period of time (~3 months), dialysis\u2010related amyloidosis was ruled out. After blood and urine tests, a diagnosis of multiple myeloma was made. Chemotherapy treatment was started, but the patient\u2019s multiple myeloma could not be suppressed and the tongue amyloidosis worsened, leading to his death 2 years and 2 months after the initial diagnosis.<\/jats:p>","DOI":"10.1155\/2024\/8836103","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:30:10Z","timestamp":1730125810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Multiple Myeloma Identified Following the Diagnosis of Amyloidosis of the Tongue"],"prefix":"10.1155","volume":"2024","author":[{"given":"Hideka","family":"Kanemoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-7406","authenticated-orcid":false,"given":"Kyoichi","family":"Obata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kadoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisho","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hotaka","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kunisada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ibaragi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2022.2147636"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045115"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-090908-120656"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023144"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.01.007"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25761"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_227_20"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2016.43.7.641"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890070064014"},{"key":"e_1_2_9_11_2","first-page":"241","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"McKenna R.","year":"2017"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60221-X"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S287922"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13083"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-225923"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-249737"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-011-2398-5"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2018.06.009"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2023.4628"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.11.011"},{"key":"e_1_2_9_21_2","first-page":"977","article-title":"Primary amyloidosis limited to tissue of mesodermal origin","volume":"11","author":"Reimann H. 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