{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:49:25Z","timestamp":1788364165541,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We present a patient at risk of misdiagnosis with multiple myeloma due to pseudohypercalcemia. Examinations showed monoclonal protein, 50% monoclonal plasma cells in bone marrow, and hypercalcemia but no osteolytic bone lesions. Follow\u2010up tests revealed pseudohypercalcemia, with elevated total calcium, but normal ionized calcium: a discrepancy due to calcium binding to monoclonal paraprotein (confirmed by laboratory experiments). Accordingly, the patient was diagnosed with smouldering myeloma. After 900\u2009days, the presence of bone lesions prompted the start of treatment for myeloma. Consequently, monoclonal paraprotein levels declined and pseudohypercalcemia dissolved. Hence, ionized calcium should be measured in monoclonal gammopathies to avoid misdiagnosis.<\/jats:p>","DOI":"10.1155\/2024\/8844335","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:33:38Z","timestamp":1724067218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hematologists\/Physicians Need to Be Aware of Pseudohypercalcemia in Monoclonal Gammopathy: Lessons from a Case Report"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1099-2894","authenticated-orcid":false,"given":"Svenja F. B. J.","family":"Mennens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Van der Spek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-3841","authenticated-orcid":false,"given":"Janneke","family":"Ruinemans-Koerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2710-881X","authenticated-orcid":false,"given":"Marcel M. G. J.","family":"Van Borren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)12331-5"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1258\/000456303322326425"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2009.009059"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-3-396"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00914965"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329102800305"},{"key":"e_1_2_9_8_2","first-page":"246","article-title":"Pseudohypercalcemia in multiple myeloma: a case report","volume":"11","author":"Ashrafi F.","year":"2017","journal-title":"International Journal of Hematology-Oncology and Stem Cell Research"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.961"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12210"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90412-1"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(73)90161-7"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1974.tb01258.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb01326.x"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198205000-00010"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00205.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400618"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.036756"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2011.11978257"},{"key":"e_1_2_9_20_2","first-page":"37","article-title":"Pseudohypercalci\u00ebmie bij de ziekte van Waldenstr\u00f6m","volume":"1","author":"Van Balveren J. H.","year":"2018","journal-title":"Laboratoriumgeneeskunde"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1353-2"},{"key":"e_1_2_9_22_2","unstructured":"TalhaM. HasanR. andWeinsteinR. S. Pseudohypercalcemia in multiple myeloma Proceedings of the 99th Annual Meeting of the Endocrine Society January 2017 Orlando FL USA."},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3609346"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.15171\/npj.2019.15"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213482892"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.07.028"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/8844335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:33:44Z","timestamp":1724067224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/8844335"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/8844335"],"URL":"https:\/\/doi.org\/10.1155\/2024\/8844335","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8844335"}}