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However, studies considering the toxicity of this plant are scarce. Develop an aqueous extract of <jats:italic>B. floribunda<\/jats:italic> considering traditional use and determine the average lethality (LD<jats:sub>50<\/jats:sub>), signs, and symptoms of toxicity. The <jats:italic>B. floribunda<\/jats:italic> extract was obtained by immersing the root bark in ultrapure water for 18\u2009hours at 4\u00b0C, under constant stirring. The test extract was administered in a single dose of 2.000\u2009mg\/kg by gavage to rats. Signs and symptoms of toxicity were determined according to the Hippocratic screening test and compared with the control group. In addition, a necropsy was performed for macroscopic evaluation of the organs in the abdominal cavity. A powder was obtained from aqueous extracts that showed the same organoleptic characteristics and emulsification capacity as those presented by the fresh root when prepared according to popular tradition. The LD<jats:sub>50<\/jats:sub> was greater than the test dose with three animals surviving. On the other hand, necropsy of dead rats showed necrosis and reduction in lung mass, in addition to the presence of foam and excessive distension of the stomach and intestines. The main symptoms of toxicity were anesthesia, ataxia, sedation, loss of muscle strength, and excessive drowsiness in the first 24\u2009hours. There was no difference between the control and extract groups with regard to body mass, food, and water intake, as well as in macroscopy of the heart, liver, lungs, intestines, spleen, pancreas, and kidneys. The aqueous extract of the <jats:italic>B. floribunda<\/jats:italic> was considered nontoxic or of very low toxicity. However, it is capable of altering the activity of the central nervous system and causing disorders in the respiratory and digestive systems.<\/jats:p>","DOI":"10.1155\/2024\/8991384","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T11:10:58Z","timestamp":1719227458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Toxicity of Aqueous Extract from <i>Bredemeyera floribunda<\/i> Root Bark in an Animal Model"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-1804","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Stela Medeiros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7561-5028","authenticated-orcid":false,"given":"Beatriz","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-6307","authenticated-orcid":false,"given":"Maria L\u00edgia","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-7018","authenticated-orcid":false,"given":"Rita","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-6088","authenticated-orcid":false,"given":"Karine","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0233-3047","authenticated-orcid":false,"given":"Danielle","family":"Bogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-4083","authenticated-orcid":false,"given":"Priscila","family":"Hiane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-3185","authenticated-orcid":false,"given":"Ricardo","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-8002","authenticated-orcid":false,"given":"Valter","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_11_1_2","article-title":"WHO expert committee on specifications for pharmaceutical preparations","author":"Abdoulaye I.","year":"2021","journal-title":"World Health Organization\u2014Technical Report Series"},{"key":"e_1_2_11_2_2","volume-title":"Who Global Report on Traditional and Complementary Medicine 2019","author":"WHO","year":"2019"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00177"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.4172\/2153-2435.1000e139"},{"key":"e_1_2_11_5_2","volume-title":"WHO Technical Report Series, No. 1010","author":"WHO","year":"2018"},{"key":"e_1_2_11_6_2","volume-title":"Pol\u00edtica e Programa Nacional de Plantas Medicinais e Fitoter\u00e1picos","author":"Brasil","year":"2016"},{"key":"e_1_2_11_7_2","volume-title":"WHO Monograph on Selected Medicinal Plants Vol 4, Journal of Chemical Information and Modeling","author":"Goyena R.","year":"2019"},{"key":"e_1_2_11_8_2","volume-title":"Dictionary of Trees South America; Nomenclature, Taxonomy and Ecology","author":"Grandtner M. 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