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Depressive complications in chronic pain are detrimental to rehabilitation. This study was aimed at determining the influence of the presence of depressive symptoms on the efficacy of physical therapy among participants with chronic low back pain (CLBP). Methods. Data was collected from a randomized controlled trial on 113 participants with CLBP. Participants were reallocated into the depressed or nondepressed groups based on the 50-cutoff point of the self-rating depression scale. All patients received 60\u2009min sessions of physical therapy twice a week for 12 weeks. The primary outcome was back-related disability. Secondary outcomes included pain ratings, sleep quality, life quality, other psychological outcomes, and minimal clinically important differences. These outcomes were collected at baseline, 12, 26, and 52 weeks. Results. 31 (27.4%) were accompanied by depressive symptoms. At 12 weeks, the initial depression score was only associated with anxiety score (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>\u03b2<\/a:mi><a:mo>=<\/a:mo><a:mn>1.196<\/a:mn><\/a:math><\/jats:inline-formula> [0.531 to 1.860], <jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>=<\/c:mo><c:mn>0.001<\/c:mn><\/c:math><\/jats:inline-formula>) and depression score (<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>\u03b2<\/e:mi><e:mo>=<\/e:mo><e:mn>0.742<\/e:mn><\/e:math><\/jats:inline-formula> [0.200 to 1.284], <jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>P<\/g:mi><g:mo>=<\/g:mo><g:mn>0.009<\/g:mn><\/g:math><\/jats:inline-formula>) in the depressed group, but the initial depression score was associated with anxiety score (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mi>\u03b2<\/i:mi><i:mo>=<\/i:mo><i:mn>0.409<\/i:mn><\/i:math><\/jats:inline-formula> [0.138 to 0.681], <jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mi>P<\/k:mi><k:mo>=<\/k:mo><k:mn>0.004<\/k:mn><\/k:math><\/jats:inline-formula>), depression score (<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mi>\u03b2<\/m:mi><m:mo>=<\/m:mo><m:mn>0.920<\/m:mn><\/m:math><\/jats:inline-formula> [0.658 to 1.184], <jats:inline-formula><o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><o:mi>P<\/o:mi><o:mo>&lt;<\/o:mo><o:mn>0.001<\/o:mn><\/o:math><\/jats:inline-formula>), sleep quality (<jats:inline-formula><q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><q:mi>\u03b2<\/q:mi><q:mo>=<\/q:mo><q:mn>0.108<\/q:mn><\/q:math><\/jats:inline-formula> [0.018 to 0.199], <jats:inline-formula><s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><s:mi>P<\/s:mi><s:mo>=<\/s:mo><s:mn>0.020<\/s:mn><\/s:math><\/jats:inline-formula>), and pain anxiety (<jats:inline-formula><u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><u:mi>\u03b2<\/u:mi><u:mo>=<\/u:mo><u:mn>0.465<\/u:mn><\/u:math><\/jats:inline-formula> [0.034 to 0.897], <jats:inline-formula><w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><w:mi>P<\/w:mi><w:mo>=<\/w:mo><w:mn>0.035<\/w:mn><\/w:math><\/jats:inline-formula>) and negatively associated with life quality (<jats:inline-formula><y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><y:mi>\u03b2<\/y:mi><y:mo>=<\/y:mo><y:mo>\u2212<\/y:mo><y:mn>0.815<\/y:mn><\/y:math><\/jats:inline-formula> [\u22121.267 to \u22120.363], <jats:inline-formula><ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><ab:mi>P<\/ab:mi><ab:mo>=<\/ab:mo><ab:mn>0.001<\/ab:mn><\/ab:math><\/jats:inline-formula>) in the nondepressed group. Conclusions. Physical therapy is effective to CLBP with depressive symptoms. A higher initial depression score may weaken the efficacy of physical therapy in the nondepressed group. Depressive complications may adversely influence intervention efficacy for CLBP. This trial is registered with ChiCTR1800016396.<\/jats:p>","DOI":"10.1155\/2024\/9065325","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T16:20:08Z","timestamp":1711988408000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Depression on Pain and Disability in Patients with Chronic Low Back Pain after Physical Therapy: A Secondary Analysis of a Randomized Controlled Trial"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-5445","authenticated-orcid":true,"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China"},{"name":"Department of Rehabilitation Medicine, Shanghai University of Medicine and Health 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