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This case report describes a 79\u2010year\u2010old patient presenting to the emergency department for painless swelling of his scrotum, penile shaft, and left lower and upper extremities with lab values consistent with acquired angioedema without identifiable lymphoreticular or rheumatic disorder on history, exam, or total body PET scan. Proper diagnosis of AAE\u2010C1\u2010INH is essential to prevent life\u2010threatening airway compromise, ensure proper therapy, and exclude lymphoreticular disorders as the etiology of AAE\u2010C1\u2010INH.<\/jats:p>","DOI":"10.1155\/2024\/9172329","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T15:19:32Z","timestamp":1726067972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Edema of the Scrotum and Penile Shaft: An Uncommon Initial Presentation of Acquired Angioedema With Low C1\u2010Inhibitor"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-520X","authenticated-orcid":false,"given":"Meghan V.","family":"Matheny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-4855","authenticated-orcid":false,"given":"Timothy","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-4343","authenticated-orcid":false,"given":"Joseph Y.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"523","article-title":"Acquired C1 inhibitor deficiency in a case of lymphosarcoma of the spleen. 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