{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:33:43Z","timestamp":1753882423628,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":260,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Peptic ulcer disease (PUD) occurs when open sores, or ulcers, form in the stomach or first part of the small intestine caused by bacterial infection (<jats:italic>H. pylori<\/jats:italic>) and\/or nonsteroidal anti\u2010inflammatory drug (NSAID) use. This study was conducted to evaluate the antiulcer effect of some plants including genus <jats:italic>Symphytum<\/jats:italic> L., and <jats:italic>Portulaca oleracea<\/jats:italic> L. on aspirin\u2010induced acute gastric ulcer in rats. Sixteen male albino rats (200\u2013210\u2009g b.wt. each) were divided into 4 groups, 4 rats each, one of them left as the control \u2212ve group while the other 3 groups orally administered with aspirin at a dose of 200\u2009mg\/kg b.wt., for gastric ulcer induction, one of them left as control +ve and the rest 2 groups were orally administered with genus <jats:italic>Symphytum<\/jats:italic> L. and <jats:italic>Portulaca oleracea<\/jats:italic> L. at a dose of 100\u2009mg\/kg b.wt., each. for seven consecutive days. Body weight gain (BWG), the length of gastric ulcer, the volume of gastric juice, the total acidity of gastric juice, and blood sample were assessed. The results showed that orally administered with genus <jats:italic>Symphytum<\/jats:italic> L. and <jats:italic>Portulaca oleracea<\/jats:italic> L. significantly reduced the length of gastric ulcer, gastric juice volume, and total acidity of gastric juice, in addition to decreasing total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), RBC, WBC, HGB, and PLT. No significant changes were observed in the pH of gastric juice among treated groups. Moreover, in comparison to <jats:italic>Portulaca oleracea<\/jats:italic> L., genus <jats:italic>Symphytum<\/jats:italic> L. showed preferable results. Accordingly, genus <jats:italic>Symphytum<\/jats:italic> L. and <jats:italic>Portulaca oleracea<\/jats:italic> L. could be used as plants as curative agents against gastric ulcer in experimental rats.<\/jats:p>","DOI":"10.1155\/2024\/9208110","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T19:50:05Z","timestamp":1726602605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiulcer Effect of Genus <i>Symphytum<\/i> L. and <i>Portulaca oleracea<\/i> L. as Investigated on Experimental Animals"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-3508","authenticated-orcid":false,"given":"El-Sayed H.","family":"Bakr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Al-Ghamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham","family":"Al-Amri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna","family":"Al-Otaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Al-Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghala","family":"Al-Matrafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad T.","family":"Kishmira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-5465","authenticated-orcid":false,"given":"Firas","family":"Azzeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areej A.","family":"Almuraee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2016.67.6.300"},{"key":"e_1_2_9_2_2","first-page":"2333","article-title":"Aspirin and nonsteroidal anti-inflammatory drug-induced gastropathy: pathogenesis, prevention, and management","volume":"95","author":"Wallace J. 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