{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:56:41Z","timestamp":1774612601332,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":260,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. <jats:italic>Streptococcus pyogenes<\/jats:italic> is the most frequent cause of pharyngitis and skin infections in children and causes immune complications like rheumatic fever and rheumatoid heart disease (RHD), particularly in developing countries like Ethiopia. The aim of this study was to determine the prevalence, antibiotic resistance pattern, and associated factors of <jats:italic>Streptococcus pyogenes<\/jats:italic> among pediatric patients suspected of acute pharyngitis in Sidama Region, Southern Ethiopia. <jats:italic>Methods<\/jats:italic>. A cross\u2010sectional study was conducted on 213 acute pharyngitis suspected pediatric patients from April to September 2022 at Hawassa University Compressive Specialized Hospital and Yirgalem Hospital. Sociodemographic and clinical data were collected using a structured questionnaire. A throat swab was cultured to isolate <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic>, and antimicrobial susceptibility testing was done using standard bacteriological techniques. Data were analyzed using SPSS version 25, and <jats:italic>P<\/jats:italic> value of &lt;0.05 was considered as statistically significant. <jats:italic>Result<\/jats:italic>. Out of 213 throat swabs cultured, 22 (10.3%) with 95% CI (6.6\u201314.6%) were <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> positive. All isolates of <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> were sensitive to penicillin and amoxicillin. In contrast, 8 (36.4%) isolates exhibited resistance to tetracycline, 7 (31.8%) to ceftriaxone, 6 (27.3%) to erythromycin, and 5 (22.7%) isolates showed multidrug resistance. The presence of palatal petechiae (<jats:italic>P<\/jats:italic> = 0.037) and tonsillar swelling or exudate (<jats:italic>P<\/jats:italic> = 0.007) were significantly associated with <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> carriage in children suspected of having acute pharyngitis. <jats:italic>Conclusion<\/jats:italic>. In this study, the prevalence of <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> among children suspected with acute pharyngitis was low compared to other studies. The isolates showed a high level of resistance to commonly used antibiotics. Therefore, the treatment of pediatric acute <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> pharyngitis should depend on an antimicrobial susceptibility test. Furthermore, evaluation of <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> pediatric acute pharyngitis risk factors and tracking of antibiotic resistance are crucial in the controlling of pediatric acute <jats:italic>S<\/jats:italic>. <jats:italic>pyogenes<\/jats:italic> pharyngitis.<\/jats:p>","DOI":"10.1155\/2024\/9282571","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:49:01Z","timestamp":1726588141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of <i>Streptococcus pyogenes<\/i> among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-7850","authenticated-orcid":false,"given":"Alemitu Beyene","family":"Gebre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-838X","authenticated-orcid":false,"given":"Demissie Assegu","family":"Fenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel Abera","family":"Negash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betelihem Jima","family":"Hayile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.4236\/aim.2022.128034"},{"key":"e_1_2_11_2_2","first-page":"37","article-title":"Antimicrobial resistance rates of Streptococcus pyogenes in a Greek tertiary care hospital: 6-year data and literature review","volume":"46","author":"Meletis G.","year":"2023","journal-title":"New Microbiologica"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.05.012"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.08.019"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5814945"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101458"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.11.109"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2353-5"},{"key":"e_1_2_11_9_2","article-title":"Throat colonization and antibiotic susceptibility of group A \u03b2-hemolytic streptococci among rheumatic heart disease patients attending a cardiac referral hospital in Tanzania, A descriptive cross-sectional study","volume":"7","author":"Chillo P.","year":"2019","journal-title":"Frontiers in Surgery"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01641-5"},{"key":"e_1_2_11_11_2","article-title":"Ramachandra: Group A, G and C \u03b2-hemolytic streptococci","volume":"3","author":"Shobha K. 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