{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:47Z","timestamp":1790949587380,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFDA026061"],"award-info":[{"award-number":["2023GXNSFDA026061"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060300"],"award-info":[{"award-number":["82060300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Identify the clinical characteristics and prognostic factors in patients with idiopathic inflammatory myopathy (IIM) combined with interstitial lung disease (ILD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> IIM\u2010ILD patients who were hospitalized at Guangxi Medical University from January 2017 to December 2022 were retrospectively analyzed and classified as having dermatomyositis (DM)\u2010ILD or \u2010ILD. Clinical and laboratory results were analyzed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were 39 males and 111 females, the mean age of disease onset was 50.4 \u00b1 12.3 years, and the median disease duration was 3 months (range: 1\u20136). Ninety\u2010seven patients had DM\u2010ILD, and 53 had ASS\u2010ILD. The DM\u2010ILD group had 72% positivity for the anti\u2010MDA5 antibody and 5.2% positivity for the anti\u2010Mi\u20102 antibody; the ASS\u2010ILD group had 67.9% positivity for the anti\u2010Jo\u20101 antibody and 17% positivity for the anti\u2010EJ antibody. Muscle symptoms, skin ulcers, rash, rapidly progressing interstitial lung disease (RP\u2010ILD), and elevated levels of serum carcinoembryonic antigen were more common in DM\u2010ILD patients (all <jats:italic>p<\/jats:italic> &lt; 0.05). However, pericardial effusion and pleural effusion, elevated creatinine kinase, and elevated C\u2010reactive protein were more common in ASS\u2010ILD patients. After a median follow\u2010up of 15.5 months, there were more deaths in the DM\u2010ILD group (42.3% vs. 13.2%, <jats:italic>p<\/jats:italic> &lt; 0.001). Multivariate Cox regression analysis showed that RP\u2010ILD, dyspnea, and the usual interstitial pneumonia type of ILD had negative associations with overall survival (OS), and arthralgia had a positive association with OS (all <jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> DM\u2010ILD patients were more prone to secondary RP\u2010ILD and skin ulcers, had milder symptoms of myositis and less severe serositis, and had lower survival rates than the ASS\u2010ILD patients. RP\u2010ILD, dyspnea, and the usual interstitial pneumonia type of ILD had adverse effects on prognosis, but arthralgia was a protective factor.<\/jats:p>","DOI":"10.1155\/2024\/9679944","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T15:58:03Z","timestamp":1727366283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An Observational Study on the Clinical Characteristics and Prognosis of Patients With Interstitial Lung Disease Secondary to Dermatomyositis and Antisynthetase 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