{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:11:06Z","timestamp":1740143466874,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015257","name":"Northeastern University","doi-asserted-by":"publisher","award":["1R41DA043974-01"],"award-info":[{"award-number":["1R41DA043974-01"]}],"id":[{"id":"10.13039\/100015257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R41DA043974-01"],"award-info":[{"award-number":["1R41DA043974-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Biomedical Imaging"],"published-print":{"date-parts":[[2024,4,13]]},"abstract":"<jats:p>Background. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:msup><a:mrow\/><a:mrow><a:mo>\u2217<\/a:mo><\/a:mrow><\/a:msup><\/a:math><\/jats:inline-formula> relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. Optimization of protocols for ferumoxytol deployment is necessary to realize its potential. Methods. We present first-in-human clinical results of the Quantitative Ultrashort Time-to-Echo Contrast Enhanced (QUTE-CE) MRA technique using the superparamagnetic iron oxide nanoparticle agent ferumoxytol for vascular imaging of the head\/brain in 15 subjects at 3.0T. The QUTE-CE MRA method was implemented on a 3T scanner using a stack-of-spirals 3D Ultrashort Time-to-Echo sequence. Time-of-flight MRA and standard TE T1-weighted (T1w) images were also collected. For comparison, gadolinium-enhanced blood pool phase images were obtained retrospectively from clinical practice. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and intraluminal signal heterogeneity (ISH) were assessed and compared across approaches with Welch\u2019s two-sided <jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>t<\/c:mi><\/c:math><\/jats:inline-formula>-test. Results. Fifteen volunteers (<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mn>54<\/e:mn><e:mo>\u00b1<\/e:mo><e:mn>17<\/e:mn><\/e:math><\/jats:inline-formula> years old, 9 women) participated. QUTE-CE MRA provided high-contrast snapshots of the arterial and venous networks with lower intraluminal heterogeneity. QUTE-CE demonstrated significantly higher SNR (<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mn>1707<\/g:mn><g:mo>\u00b1<\/g:mo><g:mn>226<\/g:mn><\/g:math><\/jats:inline-formula>), blood-tissue CNR (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mn>1447<\/i:mn><i:mo>\u00b1<\/i:mo><i:mn>189<\/i:mn><\/i:math><\/jats:inline-formula>), and lower ISH (<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mn>0.091<\/k:mn><k:mo>\u00b1<\/k:mo><k:mn>0.031<\/k:mn><\/k:math><\/jats:inline-formula>) compared to ferumoxytol T1-weighted (<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mn>551<\/m:mn><m:mo>\u00b1<\/m:mo><m:mn>171<\/m:mn><\/m:math><\/jats:inline-formula>; <jats:inline-formula><o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><o:mn>319<\/o:mn><o:mo>\u00b1<\/o:mo><o:mn>144<\/o:mn><\/o:math><\/jats:inline-formula>; <jats:inline-formula><q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><q:mn>0.186<\/q:mn><q:mo>\u00b1<\/q:mo><q:mn>0.066<\/q:mn><\/q:math><\/jats:inline-formula>, respectively) and time-of-flight (<jats:inline-formula><s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><s:mn>343<\/s:mn><s:mo>\u00b1<\/s:mo><s:mn>104<\/s:mn><\/s:math><\/jats:inline-formula>; <jats:inline-formula><u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><u:mn>269<\/u:mn><u:mo>\u00b1<\/u:mo><u:mn>82<\/u:mn><\/u:math><\/jats:inline-formula>; <jats:inline-formula><w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><w:mn>0.190<\/w:mn><w:mo>\u00b1<\/w:mo><w:mn>0.016<\/w:mn><\/w:math><\/jats:inline-formula>, respectively), with <jats:inline-formula><y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><y:mi>p<\/y:mi><y:mo>&lt;<\/y:mo><y:mn>0.001<\/y:mn><\/y:math><\/jats:inline-formula> in each comparison. The high CNR increased the depth of vessel visualization. Vessel lumina were captured with lower heterogeneity. Conclusion. Quantitative Ultrashort Time-to-Echo Contrast-Enhanced MR angiography provides approximately 5-fold superior contrast with fewer artifacts compared to other contrast-enhanced vascular imaging techniques using ferumoxytol or gadolinium, and to noncontrast time-of-flight MR angiography, for clinical vascular imaging. This trial is registered with NCT03266848.<\/jats:p>","DOI":"10.1155\/2024\/9763364","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T18:50:06Z","timestamp":1713034206000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-4045","authenticated-orcid":true,"given":"Liam","family":"Timms","sequence":"first","affiliation":[{"name":"Department of Physics, Northeastern University, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-9692","authenticated-orcid":true,"given":"Tianyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physics, Northeastern University, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-6445","authenticated-orcid":true,"given":"Ju","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-3696","authenticated-orcid":true,"given":"Codi","family":"Gharagouzloo","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-7119","authenticated-orcid":true,"given":"Vishala","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-3699","authenticated-orcid":true,"given":"Rita Maria","family":"Lahoud","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-9590","authenticated-orcid":true,"given":"John W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-1947","authenticated-orcid":true,"given":"Mukesh","family":"Harisinghani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-0734","authenticated-orcid":true,"given":"Srinivas","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Physics, Northeastern University, Boston, MA, USA"},{"name":"Department of Chemical Engineering, Northeastern University, Boston, MA, USA"},{"name":"Department of Bioengineering, Northeastern University, Boston, MA, USA"},{"name":"Theranano LLC, Newton, MA, USA"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-019-0771-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26288"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283309660"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8144"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2017.11.002"},{"first-page":"11","volume-title":"Update on FDA approach to safety issue of gadolinium retention after administration of gadolinium-based contrast agents","author":"A. 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