{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:58Z","timestamp":1787017858302,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry Research International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    leaf is used for diabetes due to its pharmacologic effects. Patients with hyperglycemia experience beta cell destruction. However, no research on risk awareness has been done to ascertain its safety. The present study describes the antidiabetic effect of\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    leaf, such as the protection of pancreatic beta cells and the induction of glycogen synthesis, before addressing the secondary effects of diabetes, such as hepatic and renal toxicity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Forty\u2010five Wistar rats weighed 160\u2009\u00b1\u200910\u2009g were divided into nine groups. All animal operations complied with the National Institute of Health (NIH) guidelines for the care and use of laboratory animals as approved by the Animal Ethical Committee, University of Jos. Group I was normal control and Group II was diabetic animals induced with alloxan. Insulin and extract doses of 200, 400, and 800\u2009mg\/kg were given to diabetic Groups III\u2010VI. Normal animals in Groups VII\u2013IX were given extract at doses of 200, 400, and 800\u2009mg\/kg for 28\u2009days. Tissues were retrieved for biochemical and histological investigations using standard techniques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    There was decrease relative body weight of diabetic animals (95.50\u2009\u00b1\u20095.50) when compared to normal control (142.75\u2009\u00b1\u200920.08) with increased levels of urea (control 6.13\u2009\u00b1\u20090.523 and diabetes 29.23\u2009\u00b1\u20091.267) and creatinine (control 0.70\u2009\u00b1\u20090.057 and diabetes 2.13\u2009\u00b1\u20090.185). Histology of the liver and pancreas also points to organ damage due to hyperglycemia. However, oral administration of extract showed antidiabetic effect with protection of pancreatic beta cells and the induction of glycogen synthesis, no glycogen was deposited in the liver, addressing the secondary effects of diabetes, such as hepatic and renal toxicity. Further discovery revealed that extract elevated antioxidant enzyme expression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Leaf extract from\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    reduces blood sugar and lessens the damage caused by hyperglycemia in the pancreas and liver.\n                  <\/jats:p>","DOI":"10.1155\/2024\/9779021","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T01:06:42Z","timestamp":1729645602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypoglycemic Assessment of Aqueous Leaf Extract of\n                    <i>Moringa oleifera<\/i>\n                    on Diabetic Wistar Rats"],"prefix":"10.1155","volume":"2024","author":[{"given":"Egbujo Ejike","family":"Amina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Adisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Matthias","family":"Gamde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-7539","authenticated-orcid":false,"given":"Etinosa Beauty","family":"Omoruyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-9933","authenticated-orcid":false,"given":"Habauka M.","family":"Kwaambwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-1787","authenticated-orcid":false,"given":"Lamech M.","family":"Mwapagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"World Health Organization Diabetes Key Facts 2020 https:\/\/www.who.int\/newsroom\/fact-sheets\/detail\/diabetes."},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v22i4.17"},{"key":"e_1_2_9_3_2","first-page":"480","article-title":"Pathogenesis of Type-2 Diabetes Mellitus and Its Complications\u2014A Narrative Review","volume":"29","author":"Farhana B.","year":"2022","journal-title":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases"},{"key":"e_1_2_9_4_2","article-title":"Standards of Medical Care in Diabetes-2020","volume":"20","author":"Disclosures","year":"2020","journal-title":"Diabetes Care"},{"key":"e_1_2_9_5_2","article-title":"Standards of Medical Care in Diabetes-2020","volume":"20","author":"Glycemic Targets","year":"2020","journal-title":"Diabetes Care"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v32i3.15"},{"key":"e_1_2_9_7_2","first-page":"439","article-title":"Evaluation of Antidiabetic Effect and Liver Function Indices of Ethanol Extracts of Moringa Oleifera and Cajanus Cajan Leaves in Alloxan-Induced Diabetic Rats","volume":"14","author":"Aja P. 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