{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:12:33Z","timestamp":1776150753024,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2024,2,22]]},"abstract":"<jats:p>Objective. To review the scientific literature related to human microbiota and cutaneous T-cell lymphoma. Methodology. An exploratory and systematic review of the articles retrieved from the bibliographic databases MEDLINE (PubMed), Embase, The Cochrane Library, and Scopus, published in the last 10\u2009years with the following descriptors: \u201clymphoma, T-cell, cutaneous,\u201d \u201cmicrobiota,\u201d \u201cMycosis Fungoides,\u201d \u201cS\u00e9zary Syndrome,\u201d \u201clymphoma, primary cutaneous anaplastic large cell,\u201d \u201cLymphomatoid Papulosis\u201d and \u201cMicrobiota,\u201d \u201cmicrobiota,\u201d \u201cMicrobial Community,\u201d and \u201cMicrobial Communities.\u201d Results. Of the 87 references retrieved, after applying the inclusion and exclusion criteria, 21 articles were selected. Most studies linking cutaneous T-cell lymphoma and the microbiota focus on the cutaneous microbiome, with Staphylococcus aureus being the main related agent. Skin colonization by this bacterium could be involved in the hyperactivation of the STAT3 inflammatory pathway and in the overproduction of IL-17, both of which are widely related to the development of more aggressive and advanced forms of cutaneous T-cell lymphoma. We also found evidence of a possible relationship between intestinal dysbiosis and the development of cutaneous T-cell lymphoma, observing a decrease in taxonomic variability and an increase in certain genera such as Prevotella in the intestinal microbiome of patients with cutaneous T-cell lymphoma. The possible etiopathogenic mechanism underlying this relationship could be explained by an increase in systemic cytokine release, promoting the hyperactivation of STAT3 at the skin level. Conclusion. There appears to be a relationship between cutaneous T-cell lymphoma and the cutaneous and intestinal microbiome, as well as a possible pathophysiological pathway involved. The possible modulation of the cutaneous and intestinal microbiome or the action on the signaling inflammatory pathway, using pharmacological tools such as JAK inhibitors or IL-17 inhibitors in the latter case, could open the possibility for future therapeutic studies for cutaneous T-cell lymphoma.<\/jats:p>","DOI":"10.1155\/2024\/9919225","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T23:50:36Z","timestamp":1708645836000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-1098","authenticated-orcid":true,"given":"Daniel","family":"Rodr\u00edguez Baeza","sequence":"first","affiliation":[{"name":"Dermatology Service, Rio Hortega University Hospital, Calle Dulzaina, 2, Valladolid 47012, Spain"},{"name":"MiBioPath Research Group, Medicine Faculty, Catholic University of Murcia (UCAM), Av. de los Jer\u00f3nimos, 135, Murcia 30107, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-6564","authenticated-orcid":true,"given":"L\u00eda","family":"Bejarano Antonio","sequence":"additional","affiliation":[{"name":"Dermatology Service, Salamanca University Hospital, Paseo de la Transici\u00f3n Espa\u00f1ola, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-5579","authenticated-orcid":true,"given":"Marta","family":"Gonz\u00e1lez de Arriba","sequence":"additional","affiliation":[{"name":"Dermatology Service, Salamanca University Hospital, Paseo de la Transici\u00f3n Espa\u00f1ola, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-679X","authenticated-orcid":true,"given":"Jos\u00e9 Antonio","family":"Pic\u00f3-Monllor","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, Pediatrics and Organic Chemistry, Miguel Hern\u00e1ndez University of Elche, Ctra. 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