{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:39:32Z","timestamp":1783762772030,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004539","name":"Kasetsart University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Dogs suffer from neuropathic pain due to several neurological disorders, particularly intervertebral disc disease. We aimed to identify alternative therapeutics for neuropathic pain relief in dogs by comparing the treatment efficacy of pregabalin and <jats:italic>Macleaya<\/jats:italic> extract against neuropathic pain from cervical spinal hyperesthesia caused by intervertebral disc disease in dogs. We evaluated 10 dogs suffering from cervical intervertebral disc disease for neuropathic pain using the filament von Frey aesthesiometer (VFA). The dogs were randomly divided into two groups, G1 (<jats:italic>n<\/jats:italic>\u2009=\u20095) was treated with 4\u2009mg\/kg of pregabalin\/12\u2009hours orally for 14\u2009days, and G2 (<jats:italic>n<\/jats:italic>\u2009=\u20095) was treated with 15\u2009mg\/kg <jats:italic>Macleaya<\/jats:italic> extract once daily orally for 14\u2009days. To detect neuropathic pain, the VFA was used to measure the sensory threshold (ST) on days 0, 7, and 14. The results revealed decreases in all ST outcomes with no significant differences between the groups on day 14 posttreatment, as well as a decrease in the severity of neurological disease in both groups on day 7 posttreatment. No significant differences were detected in hematological and biochemical profiles (alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum creatinine (SCR), urea nitrogen (BUN), and total protein (TP)) in both groups between pre\u2010 and posttreatment were not significantly different. The <jats:italic>Macleaya<\/jats:italic> extract can reduce neuropathic pain in a similar pattern to pregabalin. <jats:italic>Macleaya<\/jats:italic> extract may be effective for the treatment of neuropathic pain in dogs with spinal hyperesthesia.<\/jats:p>","DOI":"10.1155\/2024\/9939754","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:07:03Z","timestamp":1722344823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Macleaya<\/i> Extract versus Pregabalin Therapeutic Effectiveness for Neuropathic Pain in Dogs"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1483-1159","authenticated-orcid":false,"given":"Saowanee","family":"Petchnamthong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8040-3546","authenticated-orcid":false,"given":"Titiyaporn","family":"Krambunlue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1399-7208","authenticated-orcid":false,"given":"Nirut","family":"Suwanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419838383"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani11040952"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.105375"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x1201140117162802"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13411"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s130942"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.752767"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010215"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.09.054"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2754\/avb201786030223"},{"key":"e_1_2_9_11_2","first-page":"254","article-title":"Macleaya cordata extract modulates inflammation via inhibition of the NF-\u03baB and MAPK signaling pathways in porcine alveolar macrophages induced by Glaesserella parasuis","volume":"86","author":"Zeng Z.","year":"2022","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.01.001"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030658"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27492"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.09.004"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.04.017"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13147"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00012"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13041"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20210033"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.11.023"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.06.006"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.3265\/Nefrologia.pre2011.Nov.11087"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.12.1442"}],"container-title":["Veterinary Medicine International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/9939754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T14:28:09Z","timestamp":1735914489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/9939754"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Di Cerbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/9939754"],"URL":"https:\/\/doi.org\/10.1155\/2024\/9939754","archive":["Portico"],"relation":{},"ISSN":["2090-8113","2042-0048"],"issn-type":[{"value":"2090-8113","type":"print"},{"value":"2042-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9939754"}}