{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:52:24Z","timestamp":1766159544298,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":299,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904260"],"award-info":[{"award-number":["81904260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3389"],"award-info":[{"award-number":["2018JJ3389"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["22B0398"],"award-info":[{"award-number":["22B0398"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Schlemm\u2019s canal (SC) is a small circular canal in the deep part of the sclera at the junction of the sclera and cornea. As an integral component of the aqueous humor outflow, its structure and function are essential in regulating intraocular pressure (IOP). If SC develops lesions, the drainage of aqueous humor would be obstructed, leading to increased intraocular pressure and injury to the optic nerve. With the rapid development of minimally invasive glaucoma surgery, an increasing number of surgeons became familiar with SC, and the area generated substantial academic attention. The pathological mechanism and the therapy for SC that had been studied in recent years are summarized in this article, hoping to provide ideas for the treatment of glaucoma in the future.<\/jats:p>","DOI":"10.1155\/2024\/9978312","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T14:30:31Z","timestamp":1729953031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pathological Mechanism and Clinical Therapy Progress of Schlemm\u2019s Canal"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-176X","authenticated-orcid":false,"given":"Yasha","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-2570","authenticated-orcid":false,"given":"Yijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-1330","authenticated-orcid":false,"given":"Qinghua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-5667","authenticated-orcid":false,"given":"Hanyu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_1_2","DOI":"10.1016\/j.exer.2015.11.026"},{"doi-asserted-by":"publisher","key":"e_1_2_10_2_2","DOI":"10.1111\/aos.15027"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_2","DOI":"10.3389\/fcell.2022.867376"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_2","DOI":"10.2147\/opth.s293702"},{"key":"e_1_2_10_5_2","doi-asserted-by":"crossref","first-page":"26555","DOI":"10.1073\/pnas.1911837116","article-title":"Increased Stiffness and Flow Resistance of the Inner Wall of Schlemm\u2019s Canal in Glaucomatous Human Eyes","volume":"116","author":"Ahabikashi A.","year":"2019","journal-title":"Proceedings of the National Academy Sciences of the Unitec States of America"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_2","DOI":"10.3390\/ijms22179446"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_2","DOI":"10.1016\/j.preteyeres.2020.1009222020.100922"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_2","DOI":"10.18240\/ijo.2021.09.19"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_2","DOI":"10.1186\/s12886-019-1275-y"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_2","DOI":"10.4103\/ojo.ojo_147_22"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_2","DOI":"10.1016\/j.exer.2021.108711"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_2","DOI":"10.18240\/ijo.2020.05.18"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_2","DOI":"10.1167\/iovs.15-17753"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_2","DOI":"10.1016\/j.preteyeres.2020.100917"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_2","DOI":"10.1167\/iovs.63.12.15"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_2","DOI":"10.2147\/opth.s156038"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_2","DOI":"10.1111\/bph.14328"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_2","DOI":"10.3389\/fphar.2021.729249"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_2","DOI":"10.2147\/jep.s259297"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_2","DOI":"10.1002\/14651858.cd013817.pub2"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_2","DOI":"10.1038\/s41598-023-36808-8"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_2","DOI":"10.3390\/pharmaceutics12080706"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_2","DOI":"10.1097\/md.0000000000015558"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_2","DOI":"10.22608\/APO.2018298"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_2","DOI":"10.1097\/ijg.0000000000000966"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_2","DOI":"10.1007\/s00347-019-01002-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_2","DOI":"10.1136\/bjophthalmol-2020-316624"},{"doi-asserted-by":"publisher","key":"e_1_2_10_28_2","DOI":"10.1080\/02713683.2022.2084113"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_2","DOI":"10.22336\/rjo.2022.44"},{"doi-asserted-by":"publisher","key":"e_1_2_10_30_2","DOI":"10.1007\/s00417-018-4010-0"},{"doi-asserted-by":"publisher","key":"e_1_2_10_31_2","DOI":"10.2147\/opth.s178962"},{"doi-asserted-by":"publisher","key":"e_1_2_10_32_2","DOI":"10.1097\/ijg.0000000000001273"},{"doi-asserted-by":"publisher","key":"e_1_2_10_33_2","DOI":"10.1002\/14651858.cd012740.pub2"},{"doi-asserted-by":"publisher","key":"e_1_2_10_34_2","DOI":"10.1016\/j.ogla.2022.08.012"},{"doi-asserted-by":"publisher","key":"e_1_2_10_35_2","DOI":"10.2147\/opth.s388293"},{"doi-asserted-by":"publisher","key":"e_1_2_10_36_2","DOI":"10.2174\/1389200221666201217093255"},{"key":"e_1_2_10_37_2","first-page":"68","article-title":"Progress of Application of Blood-Activating and Blood-Stasis-Removing Herbs in Glaucoma","volume":"50","author":"Jiang P.","year":"2019","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_38_2","first-page":"2322","article-title":"Research Progress on Anti-Inflammatory Pharmacological Action of Components of Salvia miltiorrhiza and Its preparations","volume":"44","author":"Yuan J.","year":"2021","journal-title":"Drug Evaluation Research"},{"doi-asserted-by":"publisher","key":"e_1_2_10_39_2","DOI":"10.12659\/msm.919187"},{"key":"e_1_2_10_40_2","first-page":"814","article-title":"Research Advances of Oxidative Stress in Pathogenesis of Glaucoma and the Treatment With Natural Antioxidant Agent in Glaucoma","volume":"30","author":"Xiang S.","year":"2020","journal-title":"China Journal of Chinese Ophthalmology"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/9978312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T14:30:36Z","timestamp":1729953036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/9978312"}},"subtitle":[],"editor":[{"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/9978312"],"URL":"https:\/\/doi.org\/10.1155\/2024\/9978312","archive":["Portico"],"relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"type":"print","value":"2090-004X"},{"type":"electronic","value":"2090-0058"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9978312"}}