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Detecting MEL in the early stage can hugely increase the chance of a cure. There are several methods based on machine learning to detect MEL from dermoscopic images. However, increasing the accuracy of detection is still challenging. This paper presents a new method for MEL detection that considers the combination of deep and handcrafted time\u2013frequency local features. After short preprocessing, the convolutional neural networks (CNNs) extract the deep features. To this end, feature maps at the output of the flatten layer are considered as deep features. The scale\u2010invariant feature transform (SIFT) descriptors are handcrafted local features computed from the four subbands of one\u2010level two\u2010dimensional discrete wavelet transform (2D DWT). After the fusion of the mentioned features, semisupervised discriminant analysis (SDA) reduces the highly correlated and redundant features. The Bayesian optimizer finds the optimum parameters of the SDA and Gaussian kernel of the support vector machine (SVM) classifier to maximize the classification accuracy. The HAM10000 dataset with data augmentation is considered to assess the performance of the proposed method. Simulation results show that the proposed method reaches the accuracy and sensitivity of 94.19% and 96.22%, respectively. The most challenging parts of the proposed method are extraction of deep features and tuning the parameters of SDA and Gaussian\u2010SVM.<\/jats:p>","DOI":"10.1155\/acis\/4767052","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:58:02Z","timestamp":1743508682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fusion of Deep and Time\u2013Frequency Local Features for Melanoma Skin Cancer Detection"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4196-6917","authenticated-orcid":false,"given":"Hamidreza","family":"Eghtesaddoust","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-3303","authenticated-orcid":false,"given":"Morteza","family":"Valizadeh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-9831","authenticated-orcid":false,"given":"Mehdi Chehel","family":"Amirani","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/s22134963"},{"key":"e_1_2_10_2_2","unstructured":"WHO 2024 https:\/\/www.iarc.who.int\/cancer-type\/skin-cancer."},{"key":"e_1_2_10_3_2","article-title":"State-of-the-Art Machine Learning Techniques for Melanoma Skin Cancer Detection and Classification: A Comprehensive Review","author":"Bhatt H.","year":"2022","journal-title":"Intelligent Medicine"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0173"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.030"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2019.2895803"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573405616666200129095242"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.health.2023.100161"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sintl.2021.100128"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.health.2022.100122"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2022.104659"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15416"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2023.104779"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2021.103160"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2021.3081185"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jestch.2024.101632"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksuci.2024.101944"},{"key":"e_1_2_10_18_2","article-title":"Optimization Driven Model and Segmentation Network for Skin Cancer Detection","volume":"103","author":"Kumar K. 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