{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:21:17Z","timestamp":1759778477836,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,5]],"date-time":"2006-02-05T00:00:00Z","timestamp":1139097600000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["EB001685"],"award-info":[{"award-number":["EB001685"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biomedical Imaging"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters encoding several kinds of luciferase enzymes, which generate characteristic photons in a wide spectrum covering the infrared range. Part of the diffused light can reach the body surface of the small animal, be separated into several spectral bands using appropriate filters, and collected by a sensitive CCD camera. Here we present a bioluminescence tomography (BLT) method for a bioluminescent source reconstruction from multispectral data measured on the external surface, and demonstrate the advantages of multispectral BLT in a numerical study using a heterogeneous mouse chest phantom. The results show that the multispectral approach significantly improves the accuracy and stability of the BLT reconstruction even if the data are highly noisy.<\/jats:p>","DOI":"10.1155\/ijbi\/2006\/57614","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T12:24:41Z","timestamp":1144239881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Multispectral Bioluminescence Tomography: Methodology and Simulation"],"prefix":"10.1155","volume":"2006","author":[{"given":"Alexander X.","family":"Cong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,5]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"crossref","unstructured":"BhaumikS.andGambhirS. S. Optical imaging ofRenillaluciferase reporter gene expression in living mice 2002 99 no. 1 377\u2013382.","DOI":"10.1073\/pnas.012611099"},{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","unstructured":"ContagC. H.andBachmannM. H. Advances in in vivo bioluminescence imaging of gene expression 2002 4 235\u2013260.","DOI":"10.1146\/annurev.bioeng.4.111901.093336"},{"key":"e_1_2_1_3_2","unstructured":"RayP. WuA. M. andGambhirS. S. Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice 2003 63 no. 6 1160\u20131165."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","unstructured":"ZhaoH. DoyleT. C. CoquozO. KalishF. RiceB. W. andContagC. H. Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo 2005 10 no. 4 041210\/1\u2013041210\/9.","DOI":"10.1117\/1.2032388"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"NakajimaY. IkedaM. KimuraT. HonmaS. OhmiyaY. andHonmaK.-I. Bidirectional role of orphan nuclear receptor RORain clock gene transcriptions demonstrated by a novel reporter assay system 2004 565 no. 1\u20133 122\u2013126.","DOI":"10.1016\/S0014-5793(04)00394-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"RiceB. W. CableM. D. andNelsonM. B. In vivo imaging of light-emitting probes 2001 6 no. 4 432\u2013440.","DOI":"10.1117\/1.1413210"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","unstructured":"KloseA. D. NtziachristosV. andHielscherA. H. The inverse source problem based on the radiative transfer equation in optical molecular imaging 2005 202 no. 1 323\u2013345.","DOI":"10.1016\/j.jcp.2004.07.008"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"ArridgeS. R. SchweigerM. HiraokaM. andDelpyD. T. A finite element approach for modeling photon transport in tissue 1993 20 no. 2 pt 1 299\u2013309.","DOI":"10.1118\/1.597069"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","unstructured":"FarrellT. J. PattersonM. S. andWilsonB. A diffusion theory model of spatially resolved steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo 1992 19 no. 4 879\u2013888.","DOI":"10.1118\/1.596777"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","unstructured":"GurfinkelM. PanT. andSevick-MuracaE. M. Determination of optical properties in semi-infinite turbid media using imaging measurements of frequency-domain photon migration obtained with an intensified charge-coupled device 2004 9 no. 6 1336\u20131346.","DOI":"10.1117\/1.1803549"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"GuvenM. YaziciB. IntesX. andChanceB. Diffuse optical tomography witha priorianatomical information 2005 50 no. 12 2837\u20132858.","DOI":"10.1088\/0031-9155\/50\/12\/008"},{"key":"e_1_2_1_12_2","unstructured":"WangG. HoffmanE. A. McLennanG. WangL. V. SuterM. andMeinelJ. Development of the first bioluminescent CT scanner 2003 229(P)."},{"key":"e_1_2_1_13_2","unstructured":"WangG. HoffmanE. A. andMcLennanG. Systems and methods for bioluminescent computed tomographic reconstruction. Patent disclosure filled in July 2002; US provisional patent application filled in March 2003; US patent application filed in March 2004."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","unstructured":"WangG. LiY. andJiangM. Uniqueness theorems in bioluminescence tomography 2004 31 no. 8 2289\u20132299.","DOI":"10.1118\/1.1766420"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","unstructured":"CongW. KumarD. LiuY. CongA. andWangG. A practical method to determine the light source distribution in bioluminescent imaging 5535 679\u2013686 Proceedings of SPIE.","DOI":"10.1117\/12.560524"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"GuX. ZhangQ. LarcomL. andJiangH. Three-dimensional bioluminescence tomography with model-based reconstruction 2004 12 no. 17 3996\u20134000.","DOI":"10.1364\/OPEX.12.003996"},{"key":"e_1_2_1_17_2","series-title":"Series in Contemporary Applied Mathematics","volume-title":"Frontier and Prospect of Contemporary Applied Mathematics","author":"Jiang M.","year":"2005"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","unstructured":"CongW. WangG. KumarD.et al. Practical reconstruction method for bioluminescence tomography 2005 13 no. 18 6756\u20136771.","DOI":"10.1364\/OPEX.13.006756"},{"key":"e_1_2_1_19_2","unstructured":"KuoC. CoquozO. StearnsD. G. andRiceB. W. Diffuse luminescence tomography of in vivo bioluminescent markers using multi-spectral data 3 abstract no. 180."},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","unstructured":"AlexandrakisG. RannouF. R. andChatziioannouA. F. Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study 2005 50 no. 17 4225\u20134241.","DOI":"10.1088\/0031-9155\/50\/17\/021"},{"volume-title":"Nuclear Reactor Analysis","year":"1976","author":"Duderstadt J. J.","key":"e_1_2_1_21_2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","unstructured":"SchweigerM. ArridgeS. R. HiraokaM. andDelpyD. T. The finite element method for the propagation of light in scattering media: boundary and source conditions 1995 22 no. 11 pt 1 1779\u20131792.","DOI":"10.1118\/1.597634"},{"volume-title":"The Finite Element Method in Engineering","year":"1999","author":"Rao S. S.","key":"e_1_2_1_23_2"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","unstructured":"EggermontP. P. B. Maximum entropy regularization for Fredholm integral equations of the first kind 1993 24 no. 6 1557\u20131576.","DOI":"10.1137\/0524088"}],"container-title":["International Journal of Biomedical Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijbi\/2006\/057614.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/IJBI\/2006\/57614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T07:11:58Z","timestamp":1736320318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/IJBI\/2006\/57614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/IJBI\/2006\/57614"],"URL":"https:\/\/doi.org\/10.1155\/ijbi\/2006\/57614","archive":["Portico"],"relation":{},"ISSN":["1687-4188","1687-4196"],"issn-type":[{"type":"print","value":"1687-4188"},{"type":"electronic","value":"1687-4196"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"057614"}}