{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:22:49Z","timestamp":1779297769353,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":339,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS35069"],"award-info":[{"award-number":["RO1 NS35069"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS02138"],"award-info":[{"award-number":["RO1 NS02138"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 AG16714"],"award-info":[{"award-number":["RO1 AG16714"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS35069"],"award-info":[{"award-number":["RO1 NS35069"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS02138"],"award-info":[{"award-number":["RO1 NS02138"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 AG16714"],"award-info":[{"award-number":["RO1 AG16714"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RO1 NS35069"],"award-info":[{"award-number":["RO1 NS35069"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RO1 NS02138"],"award-info":[{"award-number":["RO1 NS02138"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RO1 AG16714"],"award-info":[{"award-number":["RO1 AG16714"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biomedical Imaging"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>In brain mapping studies of sensory, cognitive, and motor operations, specific waveforms of dynamic neural activity are predicted based on theoretical models of human information processing. For example in event\u2010related functional MRI (fMRI), the general linear model (GLM) is employed in mass\u2010univariate analyses to identify the regions whose dynamic activity closely matches the expected waveforms. By comparison multivariate analyses based on PCA or ICA provide greater flexibility in detecting spatiotemporal properties of experimental data that may strongly support alternative neuroscientific explanations. We investigated conjoint multivariate and mass\u2010univariate analyses that combine the capabilities to (1) verify activation of neural machinery we already understand and (2) discover reliable signatures of new neural machinery. We examined combinations of GLM and PCA that recover latent neural signals (waveforms and footprints) with greater accuracy than either method alone. Comparative results are illustrated with analyses of real fMRI data, adding to Monte Carlo simulation support.<\/jats:p>","DOI":"10.1155\/ijbi\/2006\/79862","type":"journal-article","created":{"date-parts":[[2006,12,27]],"date-time":"2006-12-27T08:07:13Z","timestamp":1167206833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Reciprocal Benefits of Mass\u2010Univariate and Multivariate Modeling in Brain Mapping: Applications to Event\u2010Related Functional MRI, H<sub>2<\/sub><sup>15<\/sup>O\u2010, and FDG\u2010PET"],"prefix":"10.1155","volume":"2006","author":[{"given":"James R.","family":"Moeller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Habeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10036"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0294"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.118"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1998)6:5\/6<368::AID-HBM7>3.0.CO;2-E"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.05.018"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0016"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1162\/0899766053723023"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.031"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1007"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.04.021"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.043"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199906230-00032"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/ccog.2000.0447"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2003.06.005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1642"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.112.4.715"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)49013-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1666"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1315"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn758"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1037\/\/0003-066X.57.5.341"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0732088100"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1014"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.47"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.99"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/096582199387733"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00333-1"},{"key":"e_1_2_1_28_2","volume-title":"Applied Multiple Regression\/Correlation Analysis for the Behavioral Sciences","author":"Cohen J.","year":"2003"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.11.102"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/376587a0"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03204507"},{"key":"e_1_2_1_32_2","volume-title":"A Co-planar Stereotaxic Atlas of a Human Brain","author":"Talairach J.","year":"1988"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0306"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/35084005"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0074"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0560"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061133"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/39309"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1102"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1037\/0096-1523.15.4.723"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1068\/p220229"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199702000-00003"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(00)00051-2"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0269"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0484"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13429"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2197"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.5.0872"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2003.10.019"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2004.10.010"},{"key":"e_1_2_1_52_2","unstructured":"CarbonM.andEidelbergD. Functional imaging of sequence learning in Parkinson\u2032s disease Journal of the Neurological Sciences in press."},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.024"}],"container-title":["International Journal of Biomedical Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijbi\/2006\/079862.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/IJBI\/2006\/79862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T20:31:09Z","timestamp":1717705869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/IJBI\/2006\/79862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/IJBI\/2006\/79862"],"URL":"https:\/\/doi.org\/10.1155\/ijbi\/2006\/79862","archive":["Portico"],"relation":{},"ISSN":["1687-4188","1687-4196"],"issn-type":[{"value":"1687-4188","type":"print"},{"value":"1687-4196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"079862"}}