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In addition to the functional deterioration of memory and cognition, patients with severe conditions lose their self\u2010care ability. Patients exhibiting symptoms are often attributed to aging and thus lack proper medical care. If it can be diagnosed early, the doctor can provide adequate treatments to mitigate the symptoms. Magnetic resonance imaging (MRI) can reflect the characteristics of different human tissues and organs, and is a common tool implemented in clinical examinations. In this study, we tested learning\u2010based approaches to detect disease progression in AD patients using MRI. Specifically, each patient is categorized as one of the following four classes: cognitive normal, early mild cognitive impairment, late mild cognitive impairment, and AD. To extract 3D information in MRI, we proposed a 3D convolutional neural network structure based on ResNet3D\u201018. We designed various multiclass classification frameworks. 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