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HSP70\u2019s dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target. This review explores the innovative integration of HSP70 with nanotechnology, emphasising advancements in imaging, drug delivery and combination therapies. Nanoparticles, including SPIONs, liposomes, gold nanoparticles and metal\u2013organic frameworks, demonstrate enhanced targeting and therapeutic efficacy through HSP70 modulation. Functionalized nanocarriers exploit HSP70\u2019s tumour\u2010specific overexpression to improve drug delivery, minimise off\u2010target effects and overcome the blood\u2013brain barrier. Emerging strategies such as chemophototherapy, immunotherapy and photothermal therapy leverage HSP70\u2019s interactions within the tumour microenvironment, enabling synergistic treatment modalities. The review also highlights translational challenges, including heterogeneity of GBM, regulatory hurdles and variability in the enhanced permeability and retention (EPR) effect. Integrating computational modelling, personalised approaches and adaptive trial designs is crucial for clinical translation. By bridging nanotechnology and molecular biology, HSP70\u2010targeted strategies hold transformative potential to redefine GBM diagnosis and treatment, offering hope for improved survival and quality of life.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT00054041 and NCT04628806\n                  <\/jats:p>","DOI":"10.1155\/adpp\/1847197","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:34:14Z","timestamp":1745480054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and 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