{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:04:17Z","timestamp":1781665457805,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002411","name":"Universidad ICESI","doi-asserted-by":"publisher","award":["CA04130107"],"award-info":[{"award-number":["CA04130107"]}],"id":[{"id":"10.13039\/501100002411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Type 2 diabetes mellitus is closely linked with obesity and associated metabolic dysfunctions, including insulin resistance, dyslipidemia, and chronic inflammation. Pentacyclic triterpene acids (PTAs) derived from\n                    <jats:italic>Cecropia angustifolia<\/jats:italic>\n                    are promising bioactive compounds that may help mitigate these disorders. This study investigated the effects of a PTA\u2010rich fraction on metabolic disruptions in cellular and diet\u2010induced obesity mouse models. Prediabetic C57BL\/6J mice fed on high\u2010fat diet (HFD) for 8\u2009weeks exhibited typical metabolic abnormalities, such as increased body weight, glucose intolerance, hyperinsulinemia, and dyslipidemia, which served as a baseline for assessing PTA efficacy. 8\u2010week treatment with\n                    <jats:italic>C. angustifolia<\/jats:italic>\n                    PTAs showed significant improvement in glucose metabolism, enhancing insulin sensitivity and glucose tolerance and reducing plasma insulin levels. Although PTAs did not alter body weight or lipid profiles in HFD\u2010fed mice in a sacha inchi oil (SIO) vehicle, they effectively prevented further weight gain, especially with intraperitoneal administration. Interestingly, we found that SIO, used as PTA solubilizer, yielded similar hypoglycemic and anti\u2010inflammatory outcomes, and coadministration did not yield additive or synergistic effects. Furthermore, both PTAs and SIO demonstrated in vitro anti\u2010inflammatory activity by downregulating proinflammatory gene expression, and no adverse liver, kidney, and pancreas toxicity was observed. In conclusion, PTAs from\n                    <jats:italic>Cecropia angustifolia<\/jats:italic>\n                    and SIO present potential as nontoxic, bioactive agents for modulating carbohydrate metabolism and inflammation in obesity\u2010related conditions, although further studies are warranted to optimize dosing and investigate SIO\u2019s standalone therapeutic potential.\n                  <\/jats:p>","DOI":"10.1155\/adpp\/4687213","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:36:45Z","timestamp":1756103805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Cecropia angustifolia<\/i>\n                    Pentacyclic Triterpene Acids and Sacha Inchi Oil Improve Carbohydrate Metabolism and Inflammation in Prediabetic Mice"],"prefix":"10.1155","volume":"2025","author":[{"given":"Johanna 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