{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:02:11Z","timestamp":1773010931319,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The escalating challenge of malaria management, primarily driven by antimalarial drug resistance, necessitates the urgent exploration of novel therapeutic agents. This investigation focused on characterizing the therapeutic efficacy of an aqueous stem bark extract derived from\n                    <jats:italic>Enantia chlorantha<\/jats:italic>\n                    Oliv (Annonaceae) against the parasitic burden of\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    in a rodent model. Comprehensive assessment revealed noteworthy\n                    <jats:italic>in vitro<\/jats:italic>\n                    antiplasmodial efficacy against both the\n                    <jats:italic>PfDd2<\/jats:italic>\n                    and\n                    <jats:italic>Pf3D7<\/jats:italic>\n                    strains of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    , evidenced by median inhibitory concentrations (IC50) of 1.002 and 19.040\u2009\u03bcg\/mL, respectively. Moreover, the extract demonstrated a statistically significant, dose\u2013responsive suppression of parasitemia in the\n                    <jats:italic>in vivo<\/jats:italic>\n                    model (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), achieving suppression rates between 79.00% and 96.91%. Critically, the administration of the extract mitigated malaria\u2010associated pathophysiology, including the prevention of cachexia, anemia, and elevated leukocyte counts. It concurrently facilitated the functional recovery of hepatic and renal biomarkers (e.g., transaminases, bilirubin, and creatinine), reversed indicators of cellular oxidative stress, and potentially lessened multiorgan structural damage. Collectively, these preclinical findings robustly support the substantial antimalarial capacity of\n                    <jats:italic>E. chlorantha<\/jats:italic>\n                    stem bark extract, providing scientific validation for its ethnobotanical application. Future pharmacological research is now imperative to isolate and chemically identify the specific phytochemical constituents responsible for these observed bioactivities.\n                  <\/jats:p>","DOI":"10.1155\/adpp\/5068693","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:36:51Z","timestamp":1766475411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UHPLC\/MS Profile and Antimalarial Potency of\n                    <i>Enantia chlorantha<\/i>\n                    Oliv. (Annonaceae) Stem Bark Aqueous Extract"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2271-5655","authenticated-orcid":false,"given":"Abel Narcisse","family":"Messi Betene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-9285","authenticated-orcid":false,"given":"Raceline","family":"Gounoue Kamkumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-3527","authenticated-orcid":false,"given":"Patrick Val\u00e8re","family":"Tsouh Fokou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-9184","authenticated-orcid":false,"given":"Florence","family":"Ngueguim Tsofack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2362-0135","authenticated-orcid":false,"given":"Michel Arnaud","family":"Mbock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4455-4738","authenticated-orcid":false,"given":"Eugenie Aim\u00e9e","family":"Madiesse Kemgne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7889-7183","authenticated-orcid":false,"given":"Albertine","family":"Ngako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-0196","authenticated-orcid":false,"given":"Loic Steve","family":"Ngwem Tenlep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2327-6914","authenticated-orcid":false,"given":"Marius Jaures","family":"Tsakem Nangap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8661-4449","authenticated-orcid":false,"given":"Roberto","family":"Fokou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-4102","authenticated-orcid":false,"given":"Darline","family":"Dize","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-5299","authenticated-orcid":false,"given":"Pascal","family":"Owona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-5234","authenticated-orcid":false,"given":"Mariscal Brice","family":"Tchatat Tali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-364X","authenticated-orcid":false,"given":"Fabrice","family":"Fekam Boyom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-1181","authenticated-orcid":false,"given":"Th\u00e9ophile","family":"Dimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"WHO Malaria Policy Advisory Group (MPAG) Meeting Report","author":"WHO","year":"2023"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000419"},{"key":"e_1_2_12_3_2","first-page":"302","article-title":"The Antimalarial Potential of Medicinal Plants Used for the Treatment of Malaria in Cameroonian Folk Medicine","volume":"5","author":"Titanji V. 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