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Allergen immunotherapy (AIT) is the only approach that treats the underlying cause of allergy by inducing a desensitization response to the allergen. In this study, we investigated the effectiveness and the possible desensitization mechanisms of house dust mite (HDM) allergen extract\u2010based IT against mice models of AR. The experimental mice were divided into six groups: normal group, normal group with HDM challenge, AR group, and three AR groups that received HDM\u2010IT at low, moderate, and high doses. The effectiveness of HDM\u2010IT was evaluated based on nose\u2010rubbing and sneezing behavior, IL\u20104 mRNA expression, eosinophil infiltration into nasal mucosal tissue, serum IgE levels, serum IgG2a levels, and serum IgE\/IgG2a ratio. This study discovered that the administration of HDM\u2010IT reduced nose\u2010rubbing and sneezing behavior, decreased IL\u20104 mRNA expression and eosinophil infiltration into nasal mucosal tissue, decreased serum IgE levels, increased serum IgG2a levels, and decreased serum IgE\/IgG2a ratio in AR mice. Thus, HDM\u2010IT effectively promotes a desensitization response to HDM allergens in mouse models of AR.<\/jats:p>","DOI":"10.1155\/adpp\/7002987","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:07:12Z","timestamp":1779685632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Insights Into House Dust Mites Immunotherapy\u2010Induced Desensitization for Sustained Protection of Allergic Rhinitis in Mice"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-0667","authenticated-orcid":false,"given":"Ahmad 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