{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:02:25Z","timestamp":1779706945706,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The etiological contribution of male factors to infertility remains a significant concern in reproductive health. Natural dietary products are gaining attention as promising interventions to improve male infertility. This study investigates the effects of aqueous extract of\n                    <jats:italic>Sesamum indicum<\/jats:italic>\n                    L\n                    <jats:italic>. (S. indicum)<\/jats:italic>\n                    on male reproductive parameters and potential anti\u2010infertility mechanisms. Male Sprague\u2013Dawley rats were randomly assigned to five groups: a control group (distilled water), two treatment groups receiving aqueous\n                    <jats:italic>S. indicum<\/jats:italic>\n                    extract (1.5 and 3.0\u2009g\/kg) for 30\u2009days, and corresponding recovery groups. Reproductive organs were assessed for weight and sperm parameters. Blood serum was analyzed for luteinizing hormone (LH), testosterone, and lipid profile parameters. Incorporating in silico approaches, bioactive compounds of\n                    <jats:italic>S. indicum<\/jats:italic>\n                    were screened from a database, and their targets were predicted via network pharmacology, followed by functional enrichment analyses and molecular docking. Findings show that\n                    <jats:italic>S. indicum<\/jats:italic>\n                    significantly increased (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) the weights of the hearts, adrenal glands, livers, and accessory reproductive organs. Sperm count and morphology, as well as LH and testosterone levels, were significantly increased (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Network pharmacology identified linoleic acid, oleic acid, biotin, and esculentic acid as key contributors to the extract\u2019s anti\u2010infertility effects, potentially via interactions with EGFR, HIF1, BCL2, TNF, and AKT1. These interactions, supported by favorable binding affinities, may involve antioxidative pathways. Although the exposure duration, differences in extraction methods, paucity of experimental molecular data, and algorithmic constraints represent potential limitations, the present findings provide pharmacological insights into the therapeutic role of\n                    <jats:italic>S. indicum<\/jats:italic>\n                    in male infertility.\n                  <\/jats:p>","DOI":"10.1155\/adpp\/9519972","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:04:13Z","timestamp":1779703453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <i>Sesamum indicum<\/i>\n                    L. Seed Extract on Male Reproductive Parameters and In Silico Anti\u2010Infertility Insights"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-9945","authenticated-orcid":false,"given":"John I.","family":"Ogbu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efe","family":"Omorodion-Osagie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-4313","authenticated-orcid":false,"given":"Funmileyi O.","family":"Awobajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-8021","authenticated-orcid":false,"given":"Ibiyemi I.","family":"Olatunji-Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230232"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/life13020519"},{"key":"e_1_2_12_3_2","article-title":"Impact of Oxidative Stress on Male and Female Germ Cells: Implications for Fertility","volume":"4","author":"Aitken R. J.","year":"2020","journal-title":"Reproduction"},{"key":"e_1_2_12_4_2","volume-title":"StatPearls. Treasure Island (FL)","author":"Leslie S. W.","year":"2024"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1063510"},{"key":"e_1_2_12_6_2","first-page":"45","article-title":"Influence of Genistein Aglycone on Some Male Reproductive Functions in Pubertal Holtzman Rats","volume":"5","author":"Awobajo F. O.","year":"2017","journal-title":"Journal of African Association of Physiological Sciences"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00198.x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4103\/1008-682X.155536","article-title":"Post-Testicular Sperm Maturation, Infertility, and Hypercholesterolemia","volume":"17","author":"Whitfield M.","year":"2015","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.02.103"},{"key":"e_1_2_12_10_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4103\/1008-682X.195240","article-title":"Serum Lipid Profiles are Associated with Semen Quality","volume":"19","author":"Liu C. Y.","year":"2017","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01040-8"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/2221-1691.284946"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415x.2019.1596613"},{"key":"e_1_2_12_14_2","first-page":"184","article-title":"Effect of Sesame on Sperm Quality of Infertile Men","volume":"18","author":"Khani B.","year":"2013","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_12_15_2","first-page":"1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council NRC","year":"2011"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.4314\/nqjhm.v19i1.50209"},{"key":"e_1_2_12_17_2","first-page":"159","article-title":"Implication of Reproductive Endocrine Malfunction in Male Antifertility Efficacy of Azadirachta indica Extract in Rats","volume":"32","author":"Raji Y.","year":"2003","journal-title":"African Journal of Medicine & Medical Sciences"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2275(20)31581-9"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22631-z"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2024.100857"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.08.012"},{"key":"e_1_2_12_22_2","unstructured":"PollastriM. P. Overview on the Rule of Five Current Protocols in Pharmacology 20."},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40203-026-00593-9"},{"key":"e_1_2_12_24_2","unstructured":"OliverosJ. C. VENNY. an Interactive Tool for Comparing Lists with Venn Diagrams 2007 http:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html."},{"key":"e_1_2_12_25_2","volume-title":"Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control","author":"Ogbu J. I.","year":"2026"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-00894-2"},{"key":"e_1_2_12_27_2","first-page":"121","article-title":"Profertility Effects of Alchoholic Extract of Sesame in Male Sprague-Dawley Rats","volume":"5","author":"Ukwenya V. O.","year":"2008","journal-title":"International Journal of Nutrition and Wellness"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.08.018"},{"key":"e_1_2_12_29_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0974-1208.63115","article-title":"Efficacy of Vitamin C and Ethanolic Extract of Sesamum indicum L. in Promoting Fertility in Male Wistar Rats","volume":"3","author":"Ashamu E.","year":"2010","journal-title":"Journal of Human Reproductive Sciences"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.08.109"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani12121550"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_7_20"},{"key":"e_1_2_12_33_2","first-page":"177","article-title":"Potency of Sesame Oil as Antihypercholesterolemic Agent in Rats Fed high-fat Diet","volume":"6","author":"El-Baz F.","year":"2015","journal-title":"International Journal of Pharma and Bio Sciences"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaost.2020.02.004"},{"key":"e_1_2_12_35_2","first-page":"449","article-title":"The Effects of Piper guineense Versus Sesamum indicum Aqueous Extracts on Lipid Metabolism and Antioxidants in Hypercholesterolemic Rats","volume":"42","author":"Nwozo S. O.","year":"2017","journal-title":"Iranian Journal of Medical Sciences"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.852661"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2018.1494628"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2009.11.005"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom15081190"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0303-7207(00)00257-4"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)60309-4"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2023.030379"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182292"},{"key":"e_1_2_12_44_2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.6026\/973206300191067","article-title":"Molecular Docking Analysis of Triterpenoids from Cassia fistula with Breast Cancer Targets","volume":"19","author":"Christopher I.","year":"2023","journal-title":"Bioinformation"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.104252"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42468"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.16965\/ijar.2018.245"}],"container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/adpp\/9519972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/adpp\/9519972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/adpp\/9519972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:04:16Z","timestamp":1779703456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/adpp\/9519972"}},"subtitle":[],"editor":[{"given":"Koteshwara","family":"Mudigonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/adpp\/9519972"],"URL":"https:\/\/doi.org\/10.1155\/adpp\/9519972","archive":["Portico"],"relation":{},"ISSN":["2633-4682","2633-4690"],"issn-type":[{"value":"2633-4682","type":"print"},{"value":"2633-4690","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9519972"}}