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Sub\u2010Saharan Africa (SSA) faces considerable challenges in ensuring the security of the transfusion process, particularly in the context of transfusion\u2010transmissible infections (TTIs). These difficulties are principally associated with the elevated prevalence of TTI in the region, including viral (e.g., hepatitis B, HIV and hepatitis C), bacterial (e.g., syphilis), and parasitic (e.g., malaria) diseases, among others. Also, the family replacement donation system, economic and technological limitations and an insufficient donor pool constitute substantial obstacles. Various solutions are currently being recommended, implemented, or applied on a variable scale, depending on the specific country and subregion, to address the challenges above. For instance, it would be judicious to implement measures to prevent infections, such as rigorous donor selection, quality testing for the primary TTI, and pathogen inactivation. This would necessitate deploying innovative and adapted communication strategies to establish a sufficient pool of regular, unpaid voluntary donors and high\u2010quality screening. Therefore, robust and coherent national or regional blood transfusion policies should support the previously outlined measures. These policies should include rigorous quality control and haemovigilance systems and reflect local epidemiological and economic realities.<\/jats:p>","DOI":"10.1155\/ah\/1373786","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:56:03Z","timestamp":1761702963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Issue of Screening for Transfusion\u2010Transmitted Infections in Sub\u2010Saharan Africa Presents Several Challenges: A Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1811-3166","authenticated-orcid":false,"given":"F. 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