{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:34:34Z","timestamp":1773779674670,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Diabetes is a significant worldwide health challenge associated with significant metabolic, cellular, and hematological disturbances. Hematological alterations are well\u2010documented complications of diabetes and play a crucial role in the progression of diabetes related pathology. While extensive data exist globally on hematological parameters in type 2 diabetes mellitus (T2DM), specific insights into these parameters and their local determinants within study area remain limited. Therefore, this study aimed to assess the hematological parameters among adult patients diagnosed with T2DM in JUMC at Jimma, Southwest, Ethiopia, 2024.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 200 medical charts of adults with T2DM who registered for follow\u2010up at Jimma University Medical Center were reviewed from December 2023 to February 2024. Data were collected using a data extraction checklist. Bivariate and multivariate logistic regression analyses were performed to identify factors associated with hematologic abnormalities. A\n                    <jats:italic>p<\/jats:italic>\n                    value less than 0.05 indicates statistical significance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Result:<\/jats:bold>\n                    The overall prevalence of anemia and leukocytosis in adults with T2DM was 14.0% and 12.0%, respectively. Neutrophilia was the common white blood cell (WBC) abnormality detected in 9.5% of the patients. Besides, thrombocytopenia and thrombocytosis were observed in 2.5% and 1.5% of the patients, respectively. Increasing age 5.28 (95% CI: 1.07\u201326.1) and duration of diabetes mellitus (\u2265 3\u2009years) (AOD\u2009=\u20093.1 (95% CI: 1.02\u20139.5)) were significantly associated with anemia and leukocytosis, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study found a prevalence of hematological abnormalities in adults with T2DM, including anemia, elevated WBC count, increased neutrophils, and thrombocytopenia. Anemia was associated with advanced age, while leukocytosis was associated with a longer diabetes duration. Therefore, it is recommended to start regularly screening T2DM patients for hematological abnormalities to improve clinical practice, guide treatment decisions, and develop targeted interventions.\n                  <\/jats:p>","DOI":"10.1155\/ah\/2225431","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:49:34Z","timestamp":1754304574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hematological Parameters Among Adult Patients Diagnosed With Type 2 Diabetes Mellitus at Jimma University Medical Center, Jimma, Southwest, Ethiopia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-2806","authenticated-orcid":false,"given":"Edosa","family":"Tadasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Kemal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272145"},{"key":"e_1_2_11_2_2","first-page":"1","article-title":"IDF Diabetes Atlas 2021-IDF Diabetes Atlas","author":"Diabetes Federation","year":"2021","journal-title":"IDF Off Website"},{"key":"e_1_2_11_3_2","first-page":"1","article-title":"Classification of Diabetes Mellitus","volume":"21","author":"Kazi A. A.","year":"2001","journal-title":"Clinics in Laboratory Medicine"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107839"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2005121320"},{"key":"e_1_2_11_6_2","volume-title":"Thrombosis","author":"Copley F. A. L.","year":"2008"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0490"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2013-0050"},{"key":"e_1_2_11_9_2","first-page":"482","article-title":"Hemostatic Tests in Patients With Type 2 Diabetes Mellitus","volume":"4","author":"Freire S\u00e1nchez N. B.","year":"2024","journal-title":"Salud"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0926-y"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0763-3"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pdi.1946"},{"key":"e_1_2_11_13_2","first-page":"11420","article-title":"Association of Hematological Indicies With Diabetes, Impaired Glucose Regulation and Microvascular Complications of Diabetes","volume":"8","author":"Demirtas L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_14_2","first-page":"425","article-title":"Mean Platelet Volume Increases in Type 2 Diabetes Mellitus Independent of HbA1c Level","volume":"30","author":"Cakir L.","year":"2014","journal-title":"Acta Medica"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1889"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9213074"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijh.ijh_8_18"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/cd18-0105"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/mj.mj_1_19"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.36106\/ijar\/4813855"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/app14114684"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253286"},{"key":"e_1_2_11_23_2","volume-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity","author":"Who","year":"2011"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.11648\/j.ijhpebs.20170305.11"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.923"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2006.04.009"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6627979"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/smj.smj_65_18"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2017.04.026"},{"key":"e_1_2_11_30_2","first-page":"1","article-title":"Alterations in Hematological Parameters: Could it be a Marker in Diabetes Mellitus? Mantle Cell Lymphoma View Project Multiple Myeloma View Project Alterations in Hematological Parameters: Could it be a Marker in Diabetes Mellitus?","volume":"2","author":"Abdel N.","year":"2016","journal-title":"BAOJ"},{"key":"e_1_2_11_31_2","first-page":"6279","article-title":"Significance of Hematological Parameters in Uncomplicated Diabetes Mellitus","volume":"14","author":"Bhatt N.","year":"2020","journal-title":"Indian Journal of Forensic Medical Toxicology"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.4103\/1947-489x.210115"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S97563"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121221094212"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211031126"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025125"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53416.x"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.19.2222"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.2147\/jbm.s243234"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23808"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S26917"}],"container-title":["Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/2225431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ah\/2225431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/2225431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:20:54Z","timestamp":1773768054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ah\/2225431"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ah\/2225431"],"URL":"https:\/\/doi.org\/10.1155\/ah\/2225431","archive":["Portico"],"relation":{},"ISSN":["1687-9104","1687-9112"],"issn-type":[{"value":"1687-9104","type":"print"},{"value":"1687-9112","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2225431"}}