{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:13:37Z","timestamp":1789506817173,"version":"build-2803163510"},"reference-count":169,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Long noncoding RNAs have recently emerged as major players in cancer by operating through complex structural and functional diversity in a wide range of cellular processes. Among these, certain lncRNAs, including MALAT1 and HOTAIR, have been in the limelight concerning AML for their important roles played in regulating gene expression that in turn influence the disease course of AML. This review summarizes the structure and classification of lncRNAs, mechanisms of action regarding cancer biology, and how lncRNAs such as MALAT1 and HOTAIR act as oncogenes or tumor suppressors. It also examines intricate correlations among these lncRNAs and the bone marrow microenvironment with regard to effects on AML cell proliferation, migration, and survival. In the current review, the key pathways in AML, through which MALAT1 and HOTAIR drive cellular proliferation and epigenetic processes, are discussed in detail to point out possible therapeutic targets. The interactions between MALAT1 and HOTAIR within the bone marrow microenvironment suggest the diverse involvement of lncRNAs in AML and support their applications in biomarker development and as novel avenues for targeted therapies. This review thus represents a broad overview with the intention of furthering our understanding of the lncRNA\u2010mediated pathways in AML and their use as diagnostic and therapeutic tools.<\/jats:p>","DOI":"10.1155\/ah\/3459924","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:35:42Z","timestamp":1759912542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigating the Role of HOTAIR and MALAT1 Long Noncoding RNAs and Their Relations With Bone Marrow Environment in Acute Myeloid Leukemia Subtypes: Biomarkers and Treatment Response"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-2002","authenticated-orcid":false,"given":"Hero","family":"Hamad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-042X","authenticated-orcid":false,"given":"Goran","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-8815","authenticated-orcid":false,"given":"Ranan","family":"Kardagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.08.011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100177"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.24604"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12541"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.04.009"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.679244"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192002"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00353-1"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081924"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna8030036"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.11.038"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i35.5283"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14372"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-12-2850"},{"key":"e_1_2_10_17_2","volume-title":"Oncology, MALAT1: A Druggable Long Non-Coding RNA for Targeted Anti-Cancer Approaches","author":"Amodio N.","year":"2018"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.022"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2021.103141"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197065"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.117"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2015.10"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.49067"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.950408"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0246-6"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2016.11.002"},{"key":"e_1_2_10_27_2","volume-title":"Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis","author":"Bure I. V.","year":"2022"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225573"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-016-1433-z"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03222-1"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01600-w"},{"key":"e_1_2_10_32_2","volume-title":"Steroid Receptor RNA Activator (SRA1): Unusual Bifaceted Gene Products with Suspected Relevance to Breast Cancer","author":"Leygue E. J. N.","year":"2007"},{"key":"e_1_2_10_33_2","volume-title":"Long Non-Coding RNAs: Roles in Cellular Stress Responses and Epigenetic Mechanisms Regulating Chromatin","author":"Nickerson J. A.","year":"2024"},{"key":"e_1_2_10_34_2","volume-title":"Long Noncoding RNA (lncRNA) H19: An Essential Developmental Regulator with Expanding Roles in Cancer, Stem Cell Differentiation, and Metabolic Diseases","author":"Liao J.","year":"2023"},{"key":"e_1_2_10_35_2","volume-title":"Research, Cell Cycle-Related lncRNAs as Innovative Targets to Advance Cancer Management","author":"Liang X.-R.","year":"2023"},{"key":"e_1_2_10_36_2","first-page":"1354","article-title":"Emerging Roles of LncRNA in Cancer and Therapeutic Opportunities","volume":"9","author":"Jiang M. C.","year":"2019","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.04.009"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194760"},{"key":"e_1_2_10_39_2","volume-title":"Dysregulation of Non-Coding RNAs: Roles of miRNAs and lncRNAs in the Pathogenesis of Multiple Myeloma","author":"Ismail N. H.","year":"2023"},{"key":"e_1_2_10_40_2","volume-title":"LncRNAs in Cancer: From Garbage to Junk","author":"Aprile M.","year":"2020"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00885"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/cbm-170683"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.09.024"},{"key":"e_1_2_10_44_2","volume-title":"Pharmacotherapy, Emerging Roles and Potential Clinical Applications of Long Non-coding RNAs in Hepatocellular Carcinoma","author":"Sheng J.","year":"2022"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S294378"},{"key":"e_1_2_10_46_2","volume-title":"Telomerase in Cancer: Function, Regulation, and Clinical Translation","author":"Robinson N. J.","year":"2022"},{"key":"e_1_2_10_47_2","volume-title":"The Long Non-Coding RNA H19: An Active Player With Multiple Facets to Sustain the Hallmarks of Cancer","author":"Lecerf C.","year":"2019"},{"key":"e_1_2_10_48_2","volume-title":"Long Noncoding RNAs, Emerging and Versatile Regulators of Tumor-Induced Angiogenesis","author":"Zhao J.","year":"2019"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.851004"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22840"},{"key":"e_1_2_10_51_2","volume-title":"Long Non-Coding RNAs Modulate Tumor Microenvironment to Promote Metastasis: Novel Avenue for Therapeutic Intervention","author":"Baba S. K.","year":"2023"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.40769"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061411"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01260-5"},{"key":"e_1_2_10_55_2","volume-title":"Long Noncoding RNA (lncRNA) HOTAIR: Pathogenic Roles and Therapeutic Opportunities in Gastric Cancer","author":"Kong W.","year":"2022"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-230"},{"key":"e_1_2_10_57_2","doi-asserted-by":"crossref","unstructured":"ZhuJ. LiuS. YeF.et al. Long Noncoding RNA MEG3 Interacts With P53 Protein and Regulates Partial P53 Target Genes in Hepatoma Cells 2015.","DOI":"10.1371\/journal.pone.0139790"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.12659\/msm.913308"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206928"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020216"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2018-0128"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.11.012"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003090"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03438-1"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-809"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00467-8"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01549"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.cir-23-0045"},{"key":"e_1_2_10_69_2","volume-title":"Oncology, Noncoding RNAs in Cancer Therapy Resistance and Targeted Drug Development","author":"Wang W.-T.","year":"2019"},{"key":"e_1_2_10_70_2","volume-title":"The Long Noncoding RNA Malat1: Its Physiological and Pathophysiological Functions","author":"Zhang X.","year":"2017"},{"key":"e_1_2_10_71_2","volume-title":"Research, Regulatory Networks of LncRNA MALAT-1 in Cancer","author":"Fu S.","year":"2020"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.08.065"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02433-y"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01765-3"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.12.028"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1414651"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu055"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01174-3"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114228"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.01.001"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.265"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02320-0"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-018-00570-4"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12563"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00251-19"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-604496"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.bcd-23-0144"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004226"},{"key":"e_1_2_10_89_2","article-title":"Measurable Residual Disease and Clonal Evolution in Acute Myeloid Leukemia with Focus on NPM1-Mutations","author":"Pettersson L.","year":"2021","journal-title":"Acute Myeloid Leukemia"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1409210"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137350"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0023"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.764698"},{"key":"e_1_2_10_94_2","volume-title":"Signaling, the Role of Bone Marrow Microenvironment (BMM) Cells in Acute Myeloid Leukemia (AML) Progression: Immune Checkpoints, Metabolic Checkpoints, and Signaling Pathways","author":"Bakhtiyari M.","year":"2023"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.03.004"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03929-0"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111638"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1097\/moh.0000000000000692"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122080"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.3390\/life12111770"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.3389\/frnar.2024.1334464"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01974-y"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071141"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280800"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.01.008"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5802"},{"key":"e_1_2_10_107_2","first-page":"3174","article-title":"High Expression of lncRNA MALAT1 Suggests a Biomarker of Poor Prognosis in Colorectal Cancer","volume":"7","author":"Zheng H.-T.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2020_6017"},{"key":"e_1_2_10_109_2","first-page":"9233","article-title":"Long Non-coding RNA MALAT1 Regulates Cell Proliferation, Invasion and Apoptosis by Modulating the Wnt Signaling Pathway in Squamous Cell Carcinoma","volume":"13","author":"Zhang C.","year":"2021","journal-title":"American Journal Translation Research"},{"key":"e_1_2_10_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020460"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.23736\/s0031-0808.19.03845-x"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11347-7"},{"key":"e_1_2_10_113_2","article-title":"MALAT1 Inhibits the Wnt\/\u03b2-Catenin Signaling Pathway in Colon Cancer Cells and Affects Cell Proliferation and Apoptosis","volume":"20","author":"Zhang J.","year":"2020","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"key":"e_1_2_10_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102377"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s100003"},{"key":"e_1_2_10_116_2","first-page":"7223","article-title":"HOTAIR Is Upregulated in Acute Myeloid Leukemia and that Indicates a Poor Prognosis","volume":"8","author":"Hao S.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_117_2","first-page":"1","article-title":"HOTAIR Expression and Prognostic Impact in Acute Myeloid Leukemia Patients","volume":"22","author":"Eldin R. A. A.","year":"2021","journal-title":"Egypt Journal Medicine Humanites Genetics"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.04.016"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27776"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.1253"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-017-2478-3"},{"key":"e_1_2_10_122_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci184743"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.10.011"},{"key":"e_1_2_10_124_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-2981-4"},{"key":"e_1_2_10_125_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.572323"},{"key":"e_1_2_10_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.144029"},{"key":"e_1_2_10_127_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.640587"},{"key":"e_1_2_10_128_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.268425.115"},{"key":"e_1_2_10_129_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-566018"},{"key":"e_1_2_10_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.526"},{"key":"e_1_2_10_131_2","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13394"},{"key":"e_1_2_10_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-016-9636-7"},{"key":"e_1_2_10_133_2","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20171563"},{"key":"e_1_2_10_134_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01174-2"},{"key":"e_1_2_10_135_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01709-5"},{"key":"e_1_2_10_136_2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna6040042"},{"key":"e_1_2_10_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_2_10_138_2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-1607"},{"key":"e_1_2_10_139_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123313"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113431"},{"key":"e_1_2_10_141_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051141"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052126"},{"key":"e_1_2_10_143_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02326-3"},{"key":"e_1_2_10_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14006"},{"key":"e_1_2_10_145_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00941-y"},{"key":"e_1_2_10_146_2","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2020.1867781"},{"key":"e_1_2_10_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2018.04.001"},{"key":"e_1_2_10_148_2","doi-asserted-by":"publisher","DOI":"10.1159\/000490131"},{"key":"e_1_2_10_149_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00899"},{"key":"e_1_2_10_150_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-025-03763-5"},{"key":"e_1_2_10_151_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09905-7"},{"key":"e_1_2_10_152_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110968"},{"key":"e_1_2_10_153_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422050112"},{"key":"e_1_2_10_154_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3552"},{"key":"e_1_2_10_155_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5147"},{"key":"e_1_2_10_156_2","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2017.18.6.1581"},{"key":"e_1_2_10_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.08.005"},{"key":"e_1_2_10_158_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28796"},{"key":"e_1_2_10_159_2","article-title":"Silencing Long Non-coding RNA HOTAIR Exerts Anti-oncogenic Effect on Human Acute Myeloid Leukemia via Demethylation of HOXA5","author":"Wang S.-L.","year":"2019","journal-title":"General Letters"},{"key":"e_1_2_10_160_2","first-page":"3044","article-title":"Overexpression of LncRNA-HOTAIR Promotes Chemoresistance in Acute Leukemia Cells","volume":"13","author":"Li M.-L.","year":"2020","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108244"},{"key":"e_1_2_10_162_2","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1880733"},{"key":"e_1_2_10_163_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-021-00180-x"},{"key":"e_1_2_10_164_2","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2020.1854520"},{"key":"e_1_2_10_165_2","volume-title":"The Effect of MicroRNA-143 on the Proliferation and Apoptosis of Leukemia Cell Line U-937","author":"Huang J.-L.","year":"2021"},{"key":"e_1_2_10_166_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24556"},{"key":"e_1_2_10_167_2","volume-title":"KMT2A Activates Akt\/mTOR Signaling Pathway through LncRNA-HOTAIR to Influence the Biological Behavior of AML Cells","author":"Huang Y.","year":"2022"},{"key":"e_1_2_10_168_2","article-title":"Involvement Value of FLT-3, C-Myc, STAT3, P27, and HOTAIR Gene Expression in Acute Myeloid Leukemia Patients: A Molecular Perspective to a Novel Leukemogenesis","volume":"17","author":"Esmaeli N. S.","year":"2023","journal-title":"Mechanism"},{"key":"e_1_2_10_169_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01364-6"}],"container-title":["Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/3459924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ah\/3459924","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/3459924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:21:11Z","timestamp":1773768071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ah\/3459924"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":169,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ah\/3459924"],"URL":"https:\/\/doi.org\/10.1155\/ah\/3459924","archive":["Portico"],"relation":{},"ISSN":["1687-9104","1687-9112"],"issn-type":[{"value":"1687-9104","type":"print"},{"value":"1687-9112","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3459924"}}