{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:24:49Z","timestamp":1786951489647,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":227,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Diffuse large B\u2010cell lymphoma (DLBCL) is the most common subtype of non\u2010Hodgkin lymphoma. Hematologic malignancies are known precipitants of disseminated intravascular coagulation (DIC), and the coexistence of these conditions is associated with poor outcomes; however, large\u2010scale data specifically examining concurrent DLBCL and DIC are limited. We performed a retrospective cohort study using the National Inpatient Sample (NIS) to evaluate in\u2010hospital mortality among adult hospitalizations with DIC and\/or DLBCL identified using ICD\u201010 codes. Adults aged \u2265\u200918\u2009years with a diagnosis of DLBCL and\/or DIC were included. In\u2010hospital mortality among patients with concurrent DLBCL and DIC was 54.1%, significantly higher than mortality observed in patients with either condition alone (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In multivariable analysis restricted to patients with both DLBCL and DIC, independent predictors of increased mortality included HIV\/AIDS (aOR 4.266, 95% CI: 1.886\u20139.649;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), septic shock (aOR 3.201, 95% CI: 2.305\u20134.443;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), mechanical ventilation (aOR 2.948, 95% CI: 2.175\u20133.995;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), vasopressor use (aOR 2.759, 95% CI: 1.789\u20134.255;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), chronic kidney disease (aOR 2.523, 95% CI: 1.596\u20133.989;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), acute kidney injury (aOR 1.884, 95% CI: 1.347\u20132.637;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), Black race (aOR 2.221, 95% CI: 1.418\u20133.477;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and Asian or Pacific Islander race (aOR 2.383, 95% CI: 1.329\u20134.271;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) compared to White patients. Bleeding events, thromboembolic complications, stem cell transplantation, and CAR\u2010T therapy were not independently associated with mortality. These findings demonstrate that among patients with DLBCL, the development of DIC is associated with markedly elevated in\u2010hospital mortality, driven predominantly by critical illness, organ dysfunction, and comorbidity burden rather than bleeding or thrombosis alone. Racial disparities in outcomes were independently observed after adjusting for illness severity and comorbidities, warranting further investigation. Early recognition of DIC in patients with DLBCL and aggressive management of systemic complications, particularly septic shock, respiratory failure, and renal dysfunction, may help mitigate disease severity and improve outcomes.\n                  <\/jats:p>","DOI":"10.1155\/ah\/8956944","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:44:56Z","timestamp":1786949096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Mortality in Diffuse Large B\u2010Cell Lymphoma (DLBCL) With Disseminated Intravascular Coagulation (DIC): A National Inpatient Sample Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9636-6693","authenticated-orcid":false,"given":"Safia","family":"Ansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-1795","authenticated-orcid":false,"given":"Kristy","family":"Bono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-6180","authenticated-orcid":false,"given":"Berk","family":"Madendere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-0149","authenticated-orcid":false,"given":"Anand","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-5956","authenticated-orcid":false,"given":"Joshua","family":"Kra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19860"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2023.11.004"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.12.009"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1502628"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17172"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000147769.07699.e3"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000295317.97245.2d"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02992-w"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(200011)65:3<215::aid-ajh7>3.0.co;2-7"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1854-5"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1098326"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100864"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540802454706"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-812982"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15233053"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/blctt.s361320"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262306"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-06075-2"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.03.012"}],"container-title":["Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/8956944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ah\/8956944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ah\/8956944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:44:57Z","timestamp":1786949097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ah\/8956944"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ah\/8956944"],"URL":"https:\/\/doi.org\/10.1155\/ah\/8956944","archive":["Portico"],"relation":{},"ISSN":["1687-9104","1687-9112"],"issn-type":[{"value":"1687-9104","type":"print"},{"value":"1687-9112","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8956944"}}