{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:35:29Z","timestamp":1773779729693,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":348,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Hyper\u2010CVAD protocol is a chemotherapy regimen widely used in hematological malignancies. It is considered one of most promising remission\u2010leading treatment option for adults with acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the outcomes of adults with ALL treated with the Hyper\u2010CVAD protocol in Ecuador.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective, cross\u2010sectional study compared the outcomes of ALL patients aged 15\u2009years and older treated with hyper\u2010CVAD protocol in 8 specialized centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>139 patients with ALL treated with the Hyper\u2010CVAD protocol were included. A total of 79 were female (56.8%) and the majority had a B\u2010type phenotype 130 (93.5%). A complete response (CR) was achieved in 64.3%. Relapse was confirmed in 52.7% of those who obtained CR. Negative minimal residual disease (MRD) was achieved in 20% of patients. The median overall survival (OS) was 11\u2009months (95% CI: 7.49\u201314.50) with a 5\u2010year OS of 14.0%.\u2009A total of 12 (8.6%) deceased during induction phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adult patients treated with the Hyper\u2010CVAD protocol in Ecuador achieve rates of CR, MRD, and OS lower than those presented in international cohorts, as well as higher rates of treatment\u2010related toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ah\/9995923","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T10:05:09Z","timestamp":1765793109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyper\u2010CVAD in Adults With Acute Lymphoblastic Leukemia in Ecuador: A Multicenter Retrospective 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