{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:55:46Z","timestamp":1781502946732,"version":"3.54.1"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":164,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates the relationship between prostate cancer (PCa) detection rates and prostate volume. Prostate volume may influence the diagnostic performance of MRI\u2013ultrasound (MRI\u2013US) fusion biopsy. Enlarged prostate glands present specific challenges, including reduced specificity of prostate\u2010specific antigen (PSA), anatomical alterations of the transition zone, and potential limitations in biopsy accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 1300 consecutive patients with elevated PSA and\/or abnormal digital rectal examination (DRE) who underwent MRI\u2013US fusion\u2010guided biopsy between 2014 and 2023. Patients were stratified into five prostate volume groups (&lt;\u200930, 30\u201354.9, 55\u201379.9, 80\u2013119.9, and \u2265\u2009120\u2009mL). For PI\u2010RADS\u2013based analyses, three volume categories (&lt;\u200950, 50\u2013100, and &gt;\u2009100\u2009mL) were applied. Detection rates for overall PCa and clinically significant prostate cancer (csPCa) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1203 patients were included. The overall cancer detection rate was 62.0% (746\/1203), with 39.5% (475\/1203) classified as clinically significant. Detection rates decreased significantly with increasing prostate volume, from 82.3% in prostates &lt;\u200930\u2009mL to 28.9% in prostates \u2265\u2009120\u2009mL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Intermediate groups showed detection rates of 67.1%, 50.2%, and 48.5% for volumes of 30\u201354.9, 55\u201379.9, and 80\u2013119.9\u2009mL, respectively. A similar trend was observed for csPCa detection (59.4%, 42.3%, 27.4%, 31.5%, and 24.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In multivariable analysis, prostate volume remained an independent predictor of cancer detection (OR: 0.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Stratified by PI\u2010RADS category, detection rates consistently declined with increasing prostate size. For PI\u2010RADS 5 lesions, detection decreased from 87.1% in prostates &lt;\u200950\u2009mL to 83.1% in 50\u2013100\u2009mL and 69.2% in &gt;\u2009100\u2009mL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Comparable trends were observed for PI\u2010RADS 4 lesions (78.5%, 64.0%, and 50.0%) and PI\u2010RADS 3 lesions (45.9%, 40.7%, and 31.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, larger prostates were associated with a higher proportion of anterior lesions and a decreasing rate of positive DREs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prostate volume is an independent determinant of cancer detection in MRI\u2013US fusion biopsy. Larger prostate glands are associated with significantly reduced detection rates across all PI\u2010RADS categories. These findings highlight the need to consider prostate volume in diagnostic decision\u2010making and to adapt biopsy strategies in patients with enlarged prostates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/aiu\/5999882","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:45:34Z","timestamp":1781502334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are Big Prostates a Challenge? Correlation Between Prostate Volume and Detection Rate in Fusion Biopsy of the Prostate"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7184-1098","authenticated-orcid":false,"given":"Toni","family":"Franz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4790-7772","authenticated-orcid":false,"given":"Tom","family":"Sicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-6350","authenticated-orcid":false,"given":"Julian","family":"Lueke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9920-0059","authenticated-orcid":false,"given":"Benny","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3301-9895","authenticated-orcid":false,"given":"Christoph","family":"Breininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-8329","authenticated-orcid":false,"given":"Theodore","family":"Spinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-9636","authenticated-orcid":false,"given":"Evangelos","family":"Liatsikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5668-1056","authenticated-orcid":false,"given":"Jens-Uwe","family":"Stolzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_14_1_2","volume-title":"Presented at the EAU Annual Congress Paris","author":"Eau Guidelines","year":"2024"},{"key":"e_1_2_14_2_2","volume-title":"Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF)","year":"2024"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14017"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/mou.0b013e328329a33e"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00211-9"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-006-0134-7"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.02.030"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.009"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23938"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.013"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108977"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.12960"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.195"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.03.041"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-016-0268-1"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.7456"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24286"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.05.078"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.025"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(05)65392-x"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.06.106"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3519"},{"key":"e_1_2_14_25_2","first-page":"340","article-title":"Origin and Evolution of Benign Prostatic Enlargement","volume":"15","author":"McNeal J. 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