{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:15:15Z","timestamp":1774246515558,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bulbar urethral strictures are a common cause of lower urinary tract symptoms (LUTSs) in men and frequently recur after standard endoscopic treatments. There is growing interest in identifying less invasive techniques that provide durable outcomes compared to conventional endoscopic methods. Optilume has shown favorable outcomes in prospective trials, but real\u2010world evidence, especially including treatment\u2010na\u00efve patients, remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective study in two German urology practices, including 40 men with symptomatic bulbar urethral strictures. Symptoms were assessed using the International Prostate Symptom Score (IPSS) and IPSS\u2010derived quality\u2010of\u2010life (QoL) score at baseline and at follow\u2010up. The primary endpoints were changes in IPSS and QoL; secondary endpoints included reintervention and safety. Nonparametric paired testing (Wilcoxon) and correlation analysis (Pearson) were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 29.5\u2009months. IPSS improved from a median of 19.5 (2\u201335) to 6.0 (0\u201326), and QoL improved from 5.0 (0\u20136) to 1.0 (0\u20135) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.000001). The median absolute change was \u0394IPSS \u221210.5 overall; \u0394IPSS was \u221216.5 in treatment\u2010na\u00efve patients and \u22129.5 in previously treated patients. Median \u0394QoL was \u22124.0 overall (\u22123.5 treatment\u2010na\u00efve; \u22124.0 previously treated). One patient (2.5%) was scheduled for reintervention due to subjective dissatisfaction despite IPSS improvement. Treatment\u2010na\u00efve patients showed a trend toward better outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Optilume demonstrated excellent mid\u2010term outcomes (median follow\u2010up: 29.5\u2009months) in the treatment of bulbar urethral strictures, with significant improvements in symptom burden and QoL and a low reintervention rate (2.5%) in a real\u2010world two\u2010center cohort with a nonsignificant trend toward greater symptomatic improvement in treatment\u2010na\u00efve individuals. These findings support Optilume as a viable minimally invasive option. Larger prospective studies incorporating stricture\u2010specific patient\u2010reported outcome measures and comparative designs are needed to confirm long\u2010term effectiveness, cost considerations, and optimal patient selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/aiu\/8510976","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:33:46Z","timestamp":1774244026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Coated Balloon (Optilume\n                    <sup>\u00ae<\/sup>\n                    ) Shows a Low Reintervention Rate in Patients With Bulbar Urethral Strictures: Real\u2010World Data From Two German Centers"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9571-8171","authenticated-orcid":false,"given":"Juan Jose","family":"Menendez-Suarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgi","family":"Tosev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Borgmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"Kuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.009"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.041"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.06.003"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000003826"},{"key":"e_1_2_14_5_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/bju.16566","article-title":"Decision Regret and Long-Term Success Rates After Ventral Buccal Mucosa Graft Urethroplasty","volume":"135","author":"Santiago J. 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