{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:34Z","timestamp":1783318534021,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":185,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000001","name":"Alberta Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The goal of this study was to compare the accuracy of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PSMA\u20101007 PET\/CT to contemporary conventional imaging (contrast\u2010enhanced CT scan of the chest, abdomen, and pelvis and a\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MDP whole body bone scan with SPECT\/CT of the torso) in the setting of biochemically recurrent prostate cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective nonrandomized Phase II cohort study clinical trial included 85 patients with biochemically recurrent prostate cancer (previous therapy).\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PSMA\u20101007 whole body PET\/CT imaging was performed in all patients, with conventional imaging (contrast\u2010enhanced CT scan of the chest, abdomen, and pelvis and a\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MDP whole body bone scan with SPECT\/CT of the torso) then performed within 12\u2009days. PROMISE criteria were used for PET\/CT interpretation. After a minimum 1\u2010year follow\u2010up period, lesion\u2010level and patient\u2010level analyses were performed based on previously published reference criteria (Lawhn\u2010Heath et al. 2019). The accuracy data were compared. Referring physicians were surveyed to help determine if the scans altered treatment. Categorical variables were compared using the McNemar test (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 significant).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      53 patients with a total of 72 evaluable lesions were included in the analysis.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PSMA\u20101007 PET\/CT had a higher sensitivity than conventional imaging on a lesion level (100% compared with 58.3%) and higher overall accuracy on a patient level (90.6% compared with 62.3%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The referring physicians felt that the\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PSMA\u20101007 PET\/CT scans were beneficial to the clinical care of the patient in 90.6% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Overall, the findings support the use of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PSMA\u20101007 over conventional imaging in the evaluation of patients with biochemically recurrent prostate cancer.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov.identifier: NCT04733768\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/aiu\/8550174","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:41:04Z","timestamp":1783316464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<sup>18<\/sup>\n                    F\u2010PSMA\u20101007 PET\/CT Demonstrates Higher Accuracy for Biochemically Recurrent Prostate Cancer Compared to Contemporary Conventional Imaging"],"prefix":"10.1155","volume":"2026","author":[{"given":"Zachary","family":"Stanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Woloschuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-1476","authenticated-orcid":false,"given":"Ryan","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adwait","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kolinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaid","family":"Usmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Wuest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-1332","authenticated-orcid":false,"given":"Jonathan","family":"Abele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"Canadian Cancer Society Prostate Cancer Statistics 2024 https:\/\/cancer.ca\/en\/cancer-information\/cancer-types\/prostate\/statistics."},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14020482"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18020234"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-11-1357"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2016.07.006"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2018.03.016"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.204669"},{"key":"e_1_2_11_8_2","doi-asserted-by":"crossref","unstructured":"HofmanM. 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Prostate Specific Membrane Antigen PET: Clinical Utility in Prostate Cancer Normal Patterns Pearls and Pitfalls Radiographics 38.","DOI":"10.1148\/rg.2018170108"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.05.164"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.219501"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/18129.8744"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1007\/s00259-021-05456-3","article-title":"Clinical Significance of 18F PSMA\u20101007 Avid Non\u2010Specific Bone Lesions: A Retrospective Evaluation","volume":"48","author":"Arnfeld E.","year":"2021","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.198119"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.18.20699"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17061049"},{"key":"e_1_2_11_16_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1053\/j.semnuclmed.2024.05.003","article-title":"Diagnostic Accuracy of 18F-Prostate Specific Membrane Antigen (PSMA) PET\/CT Radiotracers in Staging and Restaging of Patients With High-Risk Prostate Cancer or Biochemical Recurrence: an Overview of Reviews","volume":"55","author":"Dullea A.","year":"2024","journal-title":"Seminars in Nuclear Medicine"}],"container-title":["Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/aiu\/8550174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/aiu\/8550174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/aiu\/8550174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:41:07Z","timestamp":1783316467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/aiu\/8550174"}},"subtitle":[],"editor":[{"given":"Sreeja","family":"Dattachoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/aiu\/8550174"],"URL":"https:\/\/doi.org\/10.1155\/aiu\/8550174","archive":["Portico"],"relation":{},"ISSN":["1687-6369","1687-6377"],"issn-type":[{"value":"1687-6369","type":"print"},{"value":"1687-6377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8550174"}}