{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:18:38Z","timestamp":1788268718984,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":243,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272719"],"award-info":[{"award-number":["82272719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012724"],"award-info":[{"award-number":["2023A1515012724"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013249"],"award-info":[{"award-number":["2024A1515013249"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J5205"],"award-info":[{"award-number":["2024A04J5205"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Long noncoding RNAs (lncRNAs) are emerging as critical regulators of tumor initiation and progression through transcriptional and posttranscriptional mechanisms. UPK1A antisense RNA 1 (\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    ), a cancer\u2010associated lncRNA, has been reported to participate in oncogenic processes; however, its overall landscape across human malignancies and its biological role in therapy resistance remain poorly understood. Given the increasing importance of identifying functional lncRNAs with prognostic and therapeutic potential, this study presents a comprehensive multiomics characterization of\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    and its experimental validation in hepatocellular carcinoma (HCC). We integrated datasets from The Cancer Genome Atlas (TCGA), the Genotype\u2010Tissue Expression Project (GTEx), the cancer immunology data engine (CIDE), and the cBioPortal for cancer genomics (cBioPortal) to systematically assess its expression pattern, genomic alterations, clinical significance, and immunological associations. Our analyses revealed that\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    is significantly upregulated in multiple tumor types, with copy\u2010number amplification as the predominant genomic alteration driving its overexpression. Elevated\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    expression was correlated with advanced disease stage, poor differentiation, immune exclusion, and unfavorable prognosis, supporting its potential as a cancer type\u2010dependent biomarker. In parallel, functional studies demonstrated that hypoxia transcriptionally induces\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    in HCC, where it promotes sorafenib resistance by suppressing apoptosis. Silencing\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    restored apoptotic and enhanced sorafenib efficacy both in vitro and in vivo. Collectively, our findings suggest that\n                    <jats:italic>UPK1A-AS1<\/jats:italic>\n                    is a hypoxia\u2010inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type\u2010dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia\u2010associated drug resistance in HCC.\n                  <\/jats:p>","DOI":"10.1155\/ancp\/1554526","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:39:15Z","timestamp":1788266355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Pan\u2010Cancer Characterization of lncRNA UPK1A\u2010AS1 and Its Role in Hypoxia\u2010Associated Sorafenib Resistance in Hepatocellular Carcinoma"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0143-4057","authenticated-orcid":false,"given":"Ze-Kai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2447-0327","authenticated-orcid":false,"given":"Min-Rui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9971-3063","authenticated-orcid":false,"given":"Shu-Jie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7767-8247","authenticated-orcid":false,"given":"Yi-Da","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9141-2117","authenticated-orcid":false,"given":"Quan-Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-1313","authenticated-orcid":false,"given":"Dong-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.011"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01591-0"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-024-00693-2"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01748-y"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02253-6"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S239418"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111590"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2026.104713"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1559373"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.1.29"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_15_16_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"RC Team","year":"2021"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_15_18_2","unstructured":"CarlsonM. org.Hs.eg.db: Genome Wide Annotation for Human 2023 R Package Version 3.18.0."},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv300"},{"key":"e_1_2_15_20_2","article-title":"ggplot2: Elegant Graphics for Data Analysis","volume":"3","author":"Snow G. 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