{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:07:14Z","timestamp":1767946034234,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["2024JZ044"],"award-info":[{"award-number":["2024JZ044"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MC073"],"award-info":[{"award-number":["ZR2020MC073"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coiled\u2010coil domain\u2010containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre\u2010mRNA splicing. However, there may be a risk of cancer development in the case of disrupted mechanism, necessitating further in\u2010depth investigation of the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study was conducted by searching for various databases to implement a comprehensive cancer analysis of CCDC97. Furthermore, a competitive endogenous RNA (ceRNA) network of CCDC97 was established, which was further integrated with the reported oncogene mechanisms in the CCDC family to explain the potential reasons for its abnormal expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCDC97 is highly expressed in various cancers and closely associated with poor prognosis. CCDC97 was also strongly associated with the infiltration of various immune cells and multiple immune checkpoints in the tumor immune microenvironment. RT\u2010qPCR showed that CCDC97 was highly expressed in hepatocellular carcinoma (HCC) tissue samples. At the single\u2010cell level, CCDC97 exhibited an intimate association with depleted T cells in HCC tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In cancers, particularly in HCC CCDC97 can serve as a promising marker for immunotherapy and prognosis in cancers, particularly in HCC. More experimental verification is needed in the future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ancp\/2230769","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:05:16Z","timestamp":1767938716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Changye","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rundong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-9930","authenticated-orcid":false,"given":"Lixin","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216225"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04742-8"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30147"},{"key":"e_1_2_13_4_2","first-page":"3662","article-title":"COA3 Overexpression Promotes Non-Small Cell Lung Cancer Metastasis by Reprogramming Glucose Metabolism","volume":"12","author":"Lin H.","year":"2022","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15792"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2066759"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.10"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa407"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13528-0"},{"key":"e_1_2_13_11_2","doi-asserted-by":"crossref","unstructured":"HongW. 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