{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:56:17Z","timestamp":1791284177129,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015285","name":"Hebei Province Medical Science Research Key Project","doi-asserted-by":"publisher","award":["20250351"],"award-info":[{"award-number":["20250351"]}],"id":[{"id":"10.13039\/501100015285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the roles of RPARP\u2010AS1 and miR\u201010b\u20105p in regulating the prognosis and tumor progression of non\u2010small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 138 NSCLC patients were enrolled. Surgical specimens were stored in liquid nitrogen. All patients received 5 years of clinical follow\u2010up for prognostic assessment. In addition, multivariate Cox regression analysis was conducted to identify independent factors affecting NSCLC prognosis, and gene expression levels were quantified by reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR). Cell Counting Kit\u20108 (CCK\u20108) assays were performed to examine cell proliferation, and transwell assays were used to assess cell migration and invasion. Furthermore, nuclear\u2010cytoplasmic fractionation experiments were conducted to localize RPARP\u2010AS1 distribution. The interaction between RPARP\u2010AS1 and miR\u201010b\u20105p was examined by dual luciferase reporter assays, and downstream targets in NSCLC were predicted using databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RPARP\u2010AS1 was downregulated, while miR\u201010b\u20105p was upregulated in both NSCLC patient tissues and cells. Patients with reduced RPARP\u2010AS1 expression or increased miR\u201010b\u20105p expression had lower survival rates, accompanied by worsened tumor size, differentiation, and metastasis. oe\u2010RPARP\u2010AS1 inhibited tumor cell proliferation, migration, and invasion. However, RPARP\u2010AS1\u2010induced functional alterations in NSCLC cells were mediated by miR\u201010b\u20105p. A total of 47 overlapping genes were identified to potentially mediate downstream signaling pathways of the RPARP\u2010AS1\/miR\u201010b\u20105p axis in NSCLC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Silencing RPARP\u2010AS1 targeted miR\u201010b\u20105p to induce NSCLC cell proliferation, migration, and invasion, leading to tumor progression and poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ancp\/8817867","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:44:33Z","timestamp":1791283473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RPARP\u2010AS1 Targets miR\u201010b\u20105p to Influence Prognosis in Non\u2010Small Cell Lung Cancer and Inhibit Tumor Progression"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9902-2606","authenticated-orcid":false,"given":"Conghui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0502-2906","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2457-368X","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9698-7177","authenticated-orcid":false,"given":"Jianzhu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3573-1163","authenticated-orcid":false,"given":"Zhenlong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6811-4955","authenticated-orcid":false,"given":"Ruoshi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6955-525X","authenticated-orcid":false,"given":"Duojun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of Hebei Medical University  Shijiazhuang 050023 China  hebmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-024-04127-y"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c00013"},{"key":"e_1_2_10_3_2","first-page":"137","article-title":"A Comparison of Flow and Image DNA Cytometry in Prediction of Patient Prognosis in Surgically Resected Small Cell Lung Cancer","volume":"12","author":"Carey F. 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