{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:41Z","timestamp":1781179121950,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":161,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Colposcopy plays a central role in the evaluation of cervical intraepithelial lesions; however, its diagnostic performance varies widely. While high sensitivity is desirable, low specificity may lead to unnecessary excisional procedures. This study aimed to evaluate the diagnostic performance of colposcopy and its potential contribution to overtreatment in a tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center study included 150 patients who underwent LEEP between April 2023 and September 2024. Colposcopic impressions were compared with LEEP histopathological outcomes. Sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios were calculated. A subgroup analysis was performed for HPV16\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Colposcopy demonstrated high sensitivity (93.9%, 95% CI: 87.3\u201397.4) but low specificity (31.4%, 95% CI: 20.2\u201345.0), with an overall accuracy of 72.7% (95% CI: 65.0\u201379.2). The PPV and NPV were 72.6% (95% CI: 64.2\u201379.7) and 72.7% (95% CI: 51.9\u201386.9), respectively. The positive and negative likelihood ratios were 1.37 and 0.19. Notably, 35 patients (23.3%) were false positives.<\/jats:p>\n                    <jats:p>In HPV16\u2010positive patients, sensitivity was 80.8% (95% CI: 71.7\u201387.5), specificity was 33.3% (95% CI: 21.9\u201347.1), and accuracy was 64.7% (95% CI: 56.7\u201372.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although colposcopy is highly sensitive, its low specificity may result in substantial overtreatment, particularly in tertiary referral settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ancp\/9307280","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:15:40Z","timestamp":1781176540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy Rate of Tertiary Center Colposcopy Unit"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-906X","authenticated-orcid":false,"given":"Emre","family":"Sertel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.04.008"},{"key":"e_1_2_9_3_2","first-page":"39","article-title":"Cervical Colposcopy: Indications and Risk Assessment","volume":"102","author":"Burness J. V.","year":"2020","journal-title":"American Family Physician"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2022.0081"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000338"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2021.0051"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000334"},{"key":"e_1_2_9_9_2","article-title":"Colposcopic Accuracy in Diagnosing Squamous Intraepithelial Lesions: A Systematic Review and Meta-Analysis","volume":"23","author":"Qin D.","year":"2023","journal-title":"BMC Cancer"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3633"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02944.x"},{"key":"e_1_2_9_12_2","first-page":"815","article-title":"Evaluation of the Accuracy of Colposcopy in Detecting HSIL and Cervical Cancer","volume":"301","author":"Ruan Y.","year":"2020","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"e_1_2_9_13_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-11074-5","volume-title":"The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes","author":"Nayar R.","year":"2015"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14538"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0306"},{"key":"e_1_2_9_17_2","first-page":"45","article-title":"Servikal Premalign Lezyonlarda Kolposkopinin Yeri","volume":"18","author":"Karap\u0131nar O. S.","year":"2015","journal-title":"T\u00fcrk Jinekolojik Onkoloji Dergisi"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.10.001"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8984516"},{"key":"e_1_2_9_20_2","first-page":"e132","article-title":"Overtreatment in Cervical Cancer Screening","volume":"8","author":"Rebolj M.","year":"2023","journal-title":"Lancet Public Health"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.065"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.10.204"}],"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ancp\/9307280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ancp\/9307280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ancp\/9307280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:15:48Z","timestamp":1781176548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ancp\/9307280"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ancp\/9307280"],"URL":"https:\/\/doi.org\/10.1155\/ancp\/9307280","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"value":"2210-7177","type":"print"},{"value":"2210-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9307280"}}