{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:54:01Z","timestamp":1791183241147,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":276,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In Gabon, screening for sickle cell disease, a hereditary disorder that causes haemolytic anaemia due to the sickling of red blood cells, is systematic during pregnancy and mandatory before marriage. Several years after the implementation of these measures, this study aimed to identify the factors associated with knowledge of sickle cell disease and awareness of haemoglobin genotype among pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a multicentre, cross\u2010sectional, descriptive and analytical study conducted from May to December 2024 in three health centres in Greater Libreville. Pregnant women of any age, regardless of gestational age, who agreed to participate by giving written consent were included. Statistical analysis was performed using Epi\u2010Info software, version 7.2.3.1. Multivariable logistic regression was additionally performed to identify independent determinants of haemoglobin genotype awareness and of general knowledge of sickle cell disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 300 women with a mean age of 26.6\u2009\u00b1\u20095.9\u2009years were included. They were mostly single (56%), in training or apprenticeship (42%), with a secondary education level (54%). Haemoglobin genotype was known to 128 (42.7%) participants. Awareness of one\u2019s own genotype was independently associated with age (aOR\u2009=\u20091.12, 95% CI 1.07\u20131.18), number of antenatal visits (aOR\u2009=\u20091.46, 95% CI 1.26\u20131.69), and tertiary education (aOR\u2009=\u20095.61, 95% CI 1.66\u201319.02), whereas marital status, significant in bivariate analysis, was not an independent determinant after adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mandatory screening policies alone are insufficient to ensure adequate awareness of sickle cell disease and haemoglobin genotype. Antenatal care visits represent a concrete, currently underused opportunity for structured counselling; integrating progressive, education\u2010adapted genetic counselling into routine antenatal care should be prioritised to strengthen the public health impact of Gabon\u2019s existing screening programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/anem\/7713981","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:49:40Z","timestamp":1791182980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Knowledge of Sickle Cell Disease and Haemoglobin Genotype Awareness Among Pregnant Women in Three Health Centres in Libreville and Owendo, Gabon"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-4326","authenticated-orcid":false,"given":"Marielle","family":"Igala","sequence":"first","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick Farel","family":"Ewendje","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0082-3604","authenticated-orcid":false,"given":"Nathalie Ambounda","family":"Ledaga","sequence":"additional","affiliation":[{"name":"Department of Gynecology University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Department of Gynecology and Obstetrics Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onie Esther Ledaga","family":"Lentombo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paule Marcelle Bamba","family":"Moussounda","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella Dolores Helley","family":"Ondo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Ikhogou","family":"Mensah","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1763-3994","authenticated-orcid":false,"given":"Axel Dany Ollo","family":"Ebozogo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5154-1913","authenticated-orcid":false,"given":"Jean Bruno","family":"Boguikouma","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Health Sciences  Libreville Gabon  akdeniz.edu.tr"},{"name":"Internal Medicine Service Libreville University Hospital Center  Libreville Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oncohp.2016.05.001"},{"key":"e_1_2_15_2_2","article-title":"Neonatal Screening of Sickle Cell Disease in Gabon: A Nationwide Study","volume":"11","author":"Delicat-Loembet L. 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