{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:11:58Z","timestamp":1773000718932,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying early response to oral iron supplementation in anaemic patients is key. This study aims to assess the onset\u2010of\u2010action of oral liquid solution of ferrous gluconate, copper and manganese gluconate in adults with moderate iron deficiency anaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, open\u2010label study was conducted in France, Bulgaria and Kenya. All patients received 150\u2009mg of oral ferrous gluconate\/day for 12\u2009weeks. Eleven blood samples were taken at Day 7 and at Days 0, 3, 5, 7, 10, 14, 21, 28, 56 and 84. The primary endpoint was to assess treatment duration required to observe a +0.5\u2009g\/dL haemoglobin (Hb) level increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010five moderately anaemic patients were included in the analysis. Hb increase \u2265 0.5\u2009g\/dL was observed within 9\u201010\u2009days of treatment (0.51\u2009g\/dL at Day 10, 95% CI: 0.45\u20130.57 and\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Serum iron increased within the first 3\u2009days (mean change from baseline: 67.21\u2009\u00b1\u200991.57\u2009\u03bcg\/dL). An improvement of quality of life (physical component mean change: 8.20\u2009\u00b1\u20097.34 and mental component: 6.72\u2009\u00b1\u20096.67) was reported after treatment. The safety profile was very good.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates for the first time the rapid onset\u2010of\u2010action of oral liquid solution of ferrous gluconate and confirms its good tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT04309669<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/anem\/8866390","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:37:16Z","timestamp":1763692636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Haematologic Response to Oral Iron Treatment in Adults With Moderate Iron\u2010Deficiency Anaemia"],"prefix":"10.1155","volume":"2025","author":[{"given":"Patrice","family":"Cacoub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrick O.","family":"Otieno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Trichereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5121-6235","authenticated-orcid":false,"given":"Oc\u00e9ane","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Laure","family":"Kerveillant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Escola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Verri\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01202-2"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.07.006"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)60865-0"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14051039"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103366"},{"key":"e_1_2_14_6_2","unstructured":"French National Authority for Health (HAS) Blood Management in Pre- Peri- and Postoperative Care and in Obstetrics: Good Practice Guidelines 2022."},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000034"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd010640.pub2"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.33935"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13268"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.4488"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-023-01548-2"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01770-2"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/children9101473"},{"key":"e_1_2_14_15_2","unstructured":"French National Agency for Medicines and Health Products Safety (ANSM) Injectable Iron Salts 2025 https:\/\/ansm.sante.fr\/tableau-marr\/sel-de-fer-injectable."},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.03.045"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_1764_21"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-113636"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061575"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac106"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd004736.pub5"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/prom.s169653"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228874"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3407-5"},{"key":"e_1_2_14_25_2","unstructured":"LopezA. BelabedY. GobertO. andEscolaJ. In Vitro Study of Intestinal Absorption of Ferrous Gluconate in the Presence of Copper Gluconate Poster P002 45th Congress of the French Hematology Society April 2025."},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008978114650"},{"key":"e_1_2_14_27_2","unstructured":"World Health Organization Worldwide Prevalence of Anaemia 1993-2005 2020 https:\/\/www.who.int\/publications\/i\/item\/9789241596657."}],"container-title":["Anemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anem\/8866390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/anem\/8866390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anem\/8866390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:44:13Z","timestamp":1772991853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/anem\/8866390"}},"subtitle":[],"editor":[{"given":"Duran","family":"Canatan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/anem\/8866390"],"URL":"https:\/\/doi.org\/10.1155\/anem\/8866390","archive":["Portico"],"relation":{},"ISSN":["2090-1267","2090-1275"],"issn-type":[{"value":"2090-1267","type":"print"},{"value":"2090-1275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8866390"}}