{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:02:53Z","timestamp":1777658573727,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Labor pain is one of the most intense physiological pains experienced by women. Single\u2010shot spinal analgesia (SSSA) offers rapid and reliable labor pain relief. Combining bupivacaine with adjuvants like fentanyl or dexmedetomidine has been proposed to enhance analgesic efficacy and maternal comfort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this randomized, double\u2010blind clinical trial, 90 full\u2010term parturients in active labor were randomly allocated into three equal groups: Group B: 2.5\u2009mg intrathecal bupivacaine with 0.5\u2009mL of saline; Group BF: 2.5\u2009mg bupivacaine with 25\u2009\u03bcg fentanyl; Group BD: 2.5\u2009mg bupivacaine with 5\u2009\u03bcg dexmedetomidine. We compared the duration and onset of analgesia, pain scores on the visual analog scale (VAS), maternal satisfaction using the short assessment of patient satisfaction (SAPS), adverse effects, and neonatal outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Group BD demonstrated the fastest onset of analgesia (2.1\u2009\u00b1\u20090.7\u2009min) and the longest duration (124.2\u2009\u00b1\u200915.4\u2009min), compared to Group BF (3.6\u2009\u00b1\u20090.9\u2009min; 106.2\u2009\u00b1\u200918.9\u2009min) and Group B (4.2\u2009\u00b1\u20091.0\u2009min; 80.4\u2009\u00b1\u200914.6\u2009min) (\n p<\/jats:italic>\n < 0.001). The pattern of pain reduction over time varied across treatments; Group BD showed the most rapid and sustained decrease in pain intensity, while Group B exhibited the slowest decline. A significant time\u2009\u00d7\u2009group interaction (\n p<\/jats:italic>\n < 0.001, partial\n \u03b7<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.67, i.e., large effect size) was observed. Maternal satisfaction scores were significantly higher in Group BD (26.63\u2009\u00b1\u20092.03) than in BF (22.00\u2009\u00b1\u20093.29) or B (15.27\u2009\u00b1\u20093.68) (\n p<\/jats:italic>\n < 0.01). The incidence of itching and nausea was higher in the BF group, and mild bradycardia was found in the BD group. Apgar scores at 1 and 5\u2009min were similar in all groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Dexmedetomidine added to intrathecal bupivacaine produced good labor analgesia with high maternal satisfaction, with low side effects, and could be used as a better substitute for fentanyl.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrials.gov: NCT06823349\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/anrp\/6685169","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:14:20Z","timestamp":1777446860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Shot Intrathecal Bupivacaine With Fentanyl vs. Dexmedetomidine for Labor Analgesia: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-6686","authenticated-orcid":false,"given":"Ayman 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Reda","family":"Ragheb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/11101849.2019.1702914"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.01.011"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v19i4.10624"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2022.01.002"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/MEIA.MEIA_25_21"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aoa.0000653181.46284.c6"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_46_19"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-02055-4"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S409245"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13105"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07750-4"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1071\/AH13119"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.00919.x"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.92442"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.4197\/med.2009.30.3.365"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2024\/27\/E221"}],"container-title":["Anesthesiology 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