{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:04:32Z","timestamp":1781201072907,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Total knee arthroplasty (TKA) is a common surgical procedure that may be associated with blood loss. The aim of this study is to evaluate intraoperative hemodynamic stability during TKA under general (GA) or spinal anesthesia (SA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Any adult undergoing primary TKA under GA or SA was retrospectively selected over a 10\u2010year period and compared. The primary outcome was the presence of intraoperative hemodynamic instability, defined by starting a norepinephrine infusion, as the variation of the patient\u2019s blood pressure exceeded 30% of its baseline value for more than 5\u2009min. Secondary outcomes included intraoperative dose of ephedrine, phenylephrine, blood loss, and volume of fluid administered. Demographic and intraoperative anesthetic variables associated with norepinephrine use were entered in a multivariate logistic regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 1,441 patients; 59% received a SA. 3.6% of patients under SA required a norepinephrine infusion versus 10.4% under GA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Ephedrine administered was lower in the SA group (mean dose 19\u2009mg vs. 31\u2009mg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while phenylephrine was not statistically different (414\u2009\u03bcg for SA and 481\u2009\u03bcg for GA,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). Intraoperative blood loss was identical in both groups (402\u2009mL for SA and 415\u2009mL for GA,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35), while mean intraoperative fluid income was higher in the GA group (862\u2009mL vs. 725\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Variables associated with norepinephrine use were GA and age, among others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GA requires more norepinephrine infusion compared to SA in patients during primary TKA, suggesting intraoperative hemodynamic stability is better preserved during neuraxial anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/anrp\/9045822","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:18:44Z","timestamp":1764825524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemodynamic Stability Between Spinal and General Anesthesia in Patient Undergoing Primary Total Knee Arthroplasty: A Retrospective Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2148-0721","authenticated-orcid":false,"given":"Thomas","family":"Jeandin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1311","authenticated-orcid":false,"given":"Eric","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-3233","authenticated-orcid":false,"given":"Jean-Benoit","family":"Rossel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-8664","authenticated-orcid":false,"given":"Julien","family":"Wegrzyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-1286","authenticated-orcid":false,"given":"Matthieu","family":"Cachemaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.05.042"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.11.019"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0666-9"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.91b7.21538"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.23736\/s0375-9393.18.12383-2"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000002069"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew362"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev455"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e318286061d"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7275.1493"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.k.01682"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.5435\/jaaos-d-19-00156"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3182a1bf1c"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000001248"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.03.036"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-016-0207-0"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.5792\/ksrr.16.009"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.11.037"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.n.00662"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/aap.0000000000000055"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217939"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.01.004"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-015-0131-8"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000003260"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s56116"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000006208"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/aap.0b013e318252e901"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22647"},{"key":"e_1_2_12_29_2","first-page":"1021","article-title":"Hemodynamic Changes Associated ith Spinal and General Anesthesia for Hip Fracture Surgery in Severe ASA III Elderly Population: a Pilot Trial","volume":"79","author":"Messina A.","year":"2013","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-022-01797-0"}],"container-title":["Anesthesiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anrp\/9045822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/anrp\/9045822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anrp\/9045822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:43:24Z","timestamp":1773769404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/anrp\/9045822"}},"subtitle":[],"editor":[{"given":"Ronald G.","family":"Pearl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/anrp\/9045822"],"URL":"https:\/\/doi.org\/10.1155\/anrp\/9045822","archive":["Portico"],"relation":{},"ISSN":["1687-6962","1687-6970"],"issn-type":[{"value":"1687-6962","type":"print"},{"value":"1687-6970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9045822"}}