{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:50:41Z","timestamp":1782870641987,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":180,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0527205-3"],"award-info":[{"award-number":["2024ZD0527205-3"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing minimally invasive modified Morrow procedure may be vulnerable to postoperative pulmonary dysfunction. During cardiopulmonary bypass (CPB), lung\u2010protective ventilation has been proposed, but the optimal inspired oxygen concentration under this strategy remains unclear. This study aimed to compare different inspired oxygen concentrations under a fixed lung\u2010protective ventilation strategy during CPB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective clinical observation study involving 97 patients scheduled for modified Morrow procedures via a small right axillary incision between January 2023 and November 2023 at a single center. Patients were randomized to receive CPB ventilation with FiO\n                      <jats:sub>2<\/jats:sub>\n                      of 30%, 50%, or 100% under a standardized ultra\u2010low\u2010tidal\u2010volumelung\u2010protective strategy. The primary outcomes included the Horowitz Index (HI\u2009=\u2009PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ), respiratory index (RI\u2009=\u2009P(A\u2010a)O\n                      <jats:sub>2<\/jats:sub>\n                      \/PaO\n                      <jats:sub>2<\/jats:sub>\n                      ), and alveolar\u2013arterial oxygen pressure difference [P(A\u2010a)O\n                      <jats:sub>2<\/jats:sub>\n                      ] at six different time points within the first 24\u2009h postoperatively, as well as postoperative pulmonary complications. Secondary outcomes included plasma levels of inflammatory cytokines, endothelial glycocalyx (eGC) components, and measures of postoperative rehabilitation and other complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in terms of postoperative complications and rehabilitation among the three groups with different inspired oxygen concentrations under a fixed lung\u2010protective ventilation strategy during CPB. Compared with the 100% FiO\n                      <jats:sub>2<\/jats:sub>\n                      group, the 30% FiO\n                      <jats:sub>2<\/jats:sub>\n                      group exhibited higher HI at 6\u2009h and 24\u2009h postoperatively with lower P(A\u2010a)O\n                      <jats:sub>2<\/jats:sub>\n                      at 18\u2009h and 24\u2009h postoperatively and a lower RI at 24\u2009h postoperatively. In addition, the 30% FiO\n                      <jats:sub>2<\/jats:sub>\n                      group showed lower plasma levels of inflammatory cytokines and eGC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings indicate that the use of 30% 100% FiO\n                      <jats:sub>2<\/jats:sub>\n                      group with ultra\u2010low tidal volume ventilation during CPB in patients undergoing a modified Morrow procedure via a small right axillary incision was safe and associated with improved early postoperative oxygenation and attenuated inflammatory response.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Clinical Trial Registry: ChiCTR2400084443\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/anrp\/9078621","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:34:36Z","timestamp":1782869676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Inspired Oxygen Concentrations During Cardiopulmonary Bypass on the Pulmonary Function of Patients Undergoing a Modified Morrow Procedure via a Small Right Axillary Incision"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3873-229X","authenticated-orcid":false,"given":"Linting","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3920-9228","authenticated-orcid":false,"given":"Lixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4658-8645","authenticated-orcid":false,"given":"Meijuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4476-8468","authenticated-orcid":false,"given":"Hanwei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2646-7728","authenticated-orcid":false,"given":"Tian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0136-7113","authenticated-orcid":false,"given":"Haozhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7862-6382","authenticated-orcid":false,"given":"Jinchen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-8732","authenticated-orcid":false,"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.09.040"},{"key":"e_1_2_10_2_2","article-title":"Minimally Invasive Electro Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy via Right Infra-Axillary Incision","author":"Wang S.","year":"2025","journal-title":"The Annals of Thoracic Surgery"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.02.031"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.11.030"},{"key":"e_1_2_10_5_2","volume-title":"\u201cLow vs. High Inspiratory Oxygen Fraction During Mechanical Ventilation in Obese Patients: Impact on Postoperative Pulmonary Outcomes\u201d","author":"Zhou X.","year":"2026"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2000.9486"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12866"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs043"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2015.04.002"},{"key":"e_1_2_10_10_2","first-page":"513","article-title":"Expert Consensus on Clinical Application of Perioperative Lung-Protective Ventilation Strategies","volume":"40","author":"Strategies C S of A T F on C A of P L P","year":"2020","journal-title":"Chinese Journal of Anesthesiology"},{"key":"e_1_2_10_11_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2021.110285","article-title":"Perioperative High Inspired Oxygen Fraction Induces Atelectasis in Patients Undergoing Abdominal Surgery: A Randomized Controlled Trial","volume":"72","author":"Park M.","year":"2021","journal-title":"Journal of Clinical Anesthesia"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i3.753"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs659"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.12.022"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1387824"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1532\/hsf98.2013267"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2018.0406"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.08.108"}],"container-title":["Anesthesiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anrp\/9078621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/anrp\/9078621","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/anrp\/9078621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:34:38Z","timestamp":1782869678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/anrp\/9078621"}},"subtitle":[],"editor":[{"given":"Chao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/anrp\/9078621"],"URL":"https:\/\/doi.org\/10.1155\/anrp\/9078621","archive":["Portico"],"relation":{},"ISSN":["1687-6962","1687-6970"],"issn-type":[{"value":"1687-6962","type":"print"},{"value":"1687-6970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9078621"}}