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Three isonitrogenous and isolipidic diets, including the control (CG), an additional 6.6\u2009g\/kg of KDF, and an additional 6.0\u2009g\/kg of NaP were fed to juvenile fish twice daily. Results showed that KDF and NaP supplementation significantly increased the activities of chymotrypsin (Chy), lipase (Lip), \u03b1\u2010amylase (\u03b1\u2010amy), creatine kinase (CK), Na\n                    <jats:sup>+<\/jats:sup>\n                    K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase (Na\n                    <jats:sup>+<\/jats:sup>\n                    K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATP), \u03b3\u2010glutamyl transferase (\u03b3\u2010GT), alkaline phosphatase (AKP), glutathione peroxidase (GSH\u2010Px), total antioxidant capacity (T\u2010AOC), and superoxide dismutase (SOD) as well as the expression level of\n                    <jats:italic>Nrf2<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), while decreased the pH value, malondialdehyde (MDA) content and the mRNA level of\n                    <jats:italic>Keap1<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Dietary KDF and NaP markedly enhanced microbial \u03b1\u2010diversity and induced significant shifts in microbiota composition through selective modulation of bacterial populations, such as\n                    <jats:italic>Photobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Mycoplasma<\/jats:italic>\n                    , and\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Besides, KDF and NaP led to notable alterations in the intestinal metabolite lipidome through increasing short\u2010chain fatty acids (SCFAs) levels, upregulating the abundance of phosphatidylcholine (PC), phosphatidylethanolamine, methyl PC (MePC), lysophosphatidic acid, ceramide (Cer), sitosteryl, monogalactosyldiacylglycerol, coenzyme, and lysophosphatidylethanolamine and downregulating the abundance of sphingomyelin and monoglyceride (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The assessment of associations revealed inverse relationships of digestive and antioxidative indices with\n                    <jats:italic>Photobacterium<\/jats:italic>\n                    , but positive correlations with\n                    <jats:italic>Mycoplasma<\/jats:italic>\n                    ,\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Ruegeria<\/jats:italic>\n                    ,\n                    <jats:italic>Synechococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Nautella<\/jats:italic>\n                    ,\n                    <jats:italic>Turicibacter<\/jats:italic>\n                    , and\n                    <jats:italic>Roseovarius<\/jats:italic>\n                    . This study advances our understanding of KDF and NaP on intestinal health.\n                  <\/jats:p>","DOI":"10.1155\/anu\/5594216","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:52:03Z","timestamp":1763459523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Mechanisms of Dietary Potassium Diformate and Sodium Propionate Driving Intestinal Microbiota and Lipid Metabolites to Modulate Intestinal Health of\n                    <i>Trachinotus ovatus<\/i>"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-4215","authenticated-orcid":false,"given":"Pengwei","family":"Xun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-7368","authenticated-orcid":false,"given":"Qianqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-8742","authenticated-orcid":false,"given":"Heizhao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-7052","authenticated-orcid":false,"given":"Dexiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6660-8566","authenticated-orcid":false,"given":"Shengzhe","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanye","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-4403","authenticated-orcid":false,"given":"Chuanpeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-6035","authenticated-orcid":false,"given":"Jiahui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-1024","authenticated-orcid":false,"given":"Wei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12511"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11160-020-09614-y"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326789"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.03.060"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12317"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12416"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.04.029"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2010.09.019"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2017.12.014"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2019.02.018"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.21608\/ejabf.2018.12055"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12141"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2024.1481672"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3125196"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2024.740918"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2014.05.038"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2009.02249.x"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2016.06.027"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-016-0253-z"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.736720"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.736147"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/anu.13371"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-023-01171-y"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2009.02.043"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2023.739850"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/anu.13112"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2021.12.035"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10499-019-00446-7"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.737225"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201500899"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aqrep.2022.101020"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1586\/erm.12.33"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2022.738776"},{"key":"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