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Five isoproteic (47%) and isolipidic (23%) diets were tested: a control diet and four diets replacing 25%\u201350% of SBM with AB or PO meals (AB25, AB50, PO25, PO50). Fish fed the AB25 diet showed growth performance, feed intake (FI), and nutrient utilization comparable to the control (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05), whereas AB50 reduced growth (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) without affecting FI or nutrient utilization (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). In contrast, PO inclusion caused a progressive decline in these parameters, more pronounced at PO50, accompanied by increased hepatosomatic index (HSI) and reduced perivisceral fat index (PFI) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Apparent protein digestibility decreased in the AB50 diet (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). In PO\u2010fed fish, digestive enzyme activities reflected adaptive responses to reduced FI, including lower pepsin (PEP) and higher total alkaline proteases (TAPs), trypsin (TRY), lipase (LIP), aminopeptidase\u2010N (APN), and maltase (MAL) activities. Hematological and plasma markers remained within normal ranges, and liver histological organization was similar among treatments (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Hepatic glutathione reductase (GR) activity increased in PO diets (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), whereas AB diets remained comparable to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Overall, mushroom by\u2010product meals were physiologically safe for\n                    <jats:italic>O. mykiss<\/jats:italic>\n                    , while AB meal emerged as a promising circular alternative to SBM, supporting up to 25% replacement without compromising growth performance, feed efficiency, or nutrient utilization.\n                  <\/jats:p>","DOI":"10.1155\/anu\/6294426","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:38:52Z","timestamp":1785821932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Valorization of Mushroom By\u2010Products From\n                    <i>Agaricus bisporus<\/i>\n                    and\n                    <i>Pleurotus ostreatus<\/i>\n                    as Novel Feed Ingredients for Rainbow Trout (\n                    <i>Oncorhynchus mykiss<\/i>\n                    ) Diets"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9035-0685","authenticated-orcid":false,"given":"Carl John","family":"Saromines","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-8468","authenticated-orcid":false,"given":"Enric","family":"Gisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2445-2020","authenticated-orcid":false,"given":"Samira","family":"Reinoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-0167","authenticated-orcid":false,"given":"Maria Luisa Tello","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-8441","authenticated-orcid":false,"given":"Margarita P\u00e9rez","family":"Clavijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-9999","authenticated-orcid":false,"given":"Silvia","family":"Torrecillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"Food and Agriculture Organization of the United Nations. 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