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Adipose tissue was demonstrated as a viable source of MSCs because of the high concentration of cells and the easy access to the donor site. The purpose of this study was to evaluate the time\u2010related results of a single intra\u2010articular injection of autologous adipose\u2010derived stem cells (aASCs) in a series of patients with HOA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective study was conducted on 30 patients with HOA, who underwent an intra\u2010articular injection of aASCs between September 2018 and January 2021. Inclusion criteria for the procedure were as follows: onset of symptoms of the affected hip in the prior six or more months ago, failure of the conservative treatment (NSAIDs and\/or physiotherapy) and age &gt; 18\u2009years. Exclusion criteria were trauma in the affected hip occurred in the previous 3\u2009months, recent arthroscopic treatment, infectious joint disease, chondromatosis of the hip or any other secondary HOA, malignancy, hyaluronic acid or other injections in the previous 6\u2009months and incomplete follow\u2010up. Because a low BMI makes extremely difficult to harvest enough adipose tissue, patients with a BMI &lt; 18 were also excluded. The Oxford Hip Score, the 12\u2010item Short Form Survey and Visual Analogue Scale were used to evaluate the results of the proposed treatment at regular intervals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In 27\/30 patients, a constant improvement in pain relief, hip function and quality of life was observed during the entire follow\u2010up period of 12\u2009months. Two patients underwent a subsequent total hip arthroplasty.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The single injection of aAMSCs seems to be a valuable treatment for HOA. A constant amelioration of pain and function could be observed in most patients at 12\u2009months of follow\u2010up.\n                  <\/jats:p>","DOI":"10.1155\/aort\/3424035","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:52:37Z","timestamp":1750067557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preliminary Report on the Time\u2010Related Effect of a Single Autologous Adipose\u2010Derived Mesenchymal Stem Cells Injection in Hip Osteoarthritis: A Retrospective Observational Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-5733","authenticated-orcid":false,"given":"Adriano","family":"Braile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-5767","authenticated-orcid":false,"given":"Annalisa","family":"De 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