{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:07:14Z","timestamp":1785510434257,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":211,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Treatment"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To analyze the clinical characteristics of patients with acute immunodeficiency syndrome (AIDS) combined with\n                      <jats:italic>Talaromyces marneffei<\/jats:italic>\n                      (TM) infection of the central nervous system (CNS), thereby improving awareness toward early diagnosis and treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of eight patients with AIDS who were treated for CNS TM infection in the Guiyang Public Health Treatment Center from May 2021 to November 2022 were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of the patients was 43.50 (range: 35.00\u201358.00) years, and all eight were male. TM infection was confirmed via metagenomic next\u2010generation sequencing (mNGS) in three cases, positive cerebrospinal fluid (CSF) cultures of TM in four cases, and both in one case. CSF and blood cultures were both positive for one patient, whereas multiple blood cultures were negative for the other seven. The number of nucleated cells and the protein level in the CSF were elevated in five and six patients, respectively, and the CSF levels of glucose and chloride were low in four patients each. Seven patients had intracranial lesions upon head imaging, and all eight were discharged from the hospital with improvement after antifungal treatment. The median CD4+ T\u2010cell count was 58.50\/\u03bcL (range: 39.00\u201373.00\/\u03bcL), indicating severe immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical characteristics and CSF\u2010related examinations of patients with AIDS combined with CNS TM infection are not distinct, complicating diagnosis and increasing the likelihood of misdiagnosis. Early diagnosis and systemic antifungal therapy can improve patients\u2019 prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/arat\/9954449","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:19:02Z","timestamp":1785507542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Patients With AIDS and\n                    <i>Talaromyces marneffei<\/i>\n                    Infection of the Central Nervous System: A Retrospective Observation Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7222-4299","authenticated-orcid":false,"given":"Yunmei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1777-7063","authenticated-orcid":false,"given":"Jinhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1082-8169","authenticated-orcid":false,"given":"Xiangxi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2981-1121","authenticated-orcid":false,"given":"Yinshuang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4770-0082","authenticated-orcid":false,"given":"Xingxing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0262-0050","authenticated-orcid":false,"given":"Xiaoxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-5623","authenticated-orcid":false,"given":"Hai","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(17)30303-1"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir028"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-9-24"},{"key":"e_1_2_12_4_2","first-page":"61","article-title":"13th Five-Year National Science and Technology Major Special AIDS Opportunistic Infection Research Group. Expert Consensus on Clinical Diagnosis and Treatment of AIDS Complicated With Marneffei Basiform Mycosis","volume":"42","year":"2019","journal-title":"Journal of Southwest University"},{"key":"e_1_2_12_5_2","first-page":"308","article-title":"Diagnosis and Treatment Status and Research Progress of AIDS Complicated With Cyanobacteria Marneffei","volume":"14","author":"Zhou Y.","year":"2019","journal-title":"Chinese Journal of Mycoliology"},{"key":"e_1_2_12_6_2","first-page":"1182","article-title":"Infectious Diseases Branch, Chinese Medical Association, Chinese Center for Disease Control and Prevention. China AIDS Diagnosis and Treatment Guidelines (2021 Edition)","volume":"27","author":"Hiv\/Aids Hepatitis C Group","year":"2021","journal-title":"China AIDS STD"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.551426"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/657400"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-020-00281-4"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.13419\/j.carolcarrollnkiAIDS.2021.05.32"},{"key":"e_1_2_12_11_2","first-page":"369","article-title":"Clinical Analysis of 36 Cases of AIDS Complicated With Disseminated Penicilliosis Marneffei","volume":"28","author":"Zhang G. L.","year":"2015","journal-title":"Infectious Diseases Information"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-021-01032-5"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9010059"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.13419\/j.carolcarrollnkiAIDS.2024.06.02"},{"key":"e_1_2_12_15_2","first-page":"3","article-title":"A Case of Central Nervous System Infection of AIDS With Marneffei Bacillus","volume":"39","author":"Mei-Qin C.","year":"2021","journal-title":"Chinese Journal of Infectious Diseases"}],"container-title":["AIDS Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/arat\/9954449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/arat\/9954449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/arat\/9954449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:19:06Z","timestamp":1785507546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/arat\/9954449"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/arat\/9954449"],"URL":"https:\/\/doi.org\/10.1155\/arat\/9954449","archive":["Portico"],"relation":{},"ISSN":["2090-1240","2090-1259"],"issn-type":[{"value":"2090-1240","type":"print"},{"value":"2090-1259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9954449"}}