{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:42:57Z","timestamp":1792590177950,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Direct\u2010acting antivirals (DAAs) have transformed the management of chronic hepatitis C virus (HCV) infection, including in children. However, real\u2010world data from resource\u2010limited settings remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of children with chronic HCV infection treated at the national pediatric hepatology center in Tirana, Albania, between 2007 and 2024. Patients were grouped according to treatment era: interferon\u2010based therapy or DAA regimens. Sustained virologic response (SVR), adverse events, and treatment duration were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine children were included (17 interferon era; 12 DAA era). SVR was achieved in 83% of patients receiving interferon\u2010based therapy and in all patients treated with DAAs. Adverse events were more frequent and clinically significant in the interferon group, whereas only mild events were observed in the DAA group. Treatment duration was substantially shorter with DAAs (8\u201312\u2009weeks vs. 48\u2009weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real\u2010world experience reflects the transition toward shorter, better\u2010tolerated, and highly effective therapies for pediatric HCV infection. While cross\u2010era comparisons are limited, the findings are consistent with the established efficacy of DAA regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/av\/2405090","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:03:24Z","timestamp":1792587804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transition From Interferon\u2010Based Therapy to Direct\u2010Acting Antivirals in Albanian Children With Chronic Hepatitis C: A 17\u2010Year Real\u2010World Experience"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-7258","authenticated-orcid":false,"given":"Virtut","family":"Velmishi","sequence":"first","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-0277","authenticated-orcid":false,"given":"Ermira","family":"Dervishi","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3578-3431","authenticated-orcid":false,"given":"Gladiola","family":"Hoxha","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blerina","family":"Saraci","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-9559","authenticated-orcid":false,"given":"Donjeta","family":"Bali","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Xhafa","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirzana","family":"Kapllanaj","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-5236","authenticated-orcid":false,"given":"Enkeleda","family":"Duka","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Shundi","sequence":"additional","affiliation":[{"name":"Institute of Public Health  Tirana Albania  cam.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-9926","authenticated-orcid":false,"given":"Paskal","family":"Cullufi","sequence":"additional","affiliation":[{"name":"Pediatric Department \u201cMother Teresa\u201d Hospital  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"Statpearls. 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