{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:10:34Z","timestamp":1788307834479,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":312,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine\u2010containing enzyme ID\u20101 by reacting with the selenenyl iodide intermediate (E\u2010SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)\u2010catalyzed oxidation and iodination reactions by antithyroid drugs are described.<\/jats:p>","DOI":"10.1155\/bca\/2006\/23214","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T07:10:06Z","timestamp":1163661006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase\u2010Catalyzed Oxidation and Iodination Reactions"],"prefix":"10.1155","volume":"2006","author":[{"given":"Gouriprasanna","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mugesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"51","article-title":"Hormone synthesis: thyroid iodine","author":"Taurog A","year":"1991","journal-title":"Werner and Ingbar\u2032s the Thyroid"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1474"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1475"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498259509061891"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0222"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80905-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/349438a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98657-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211267"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.15.070195.001543"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.655"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(99)80105-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.1.38"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)47014-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.841"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0034"},{"key":"e_1_2_1_17_2","first-page":"189","article-title":"Biochemistry of deiodination","author":"Leonard J L","year":"1986","journal-title":"Thyroid Hormone Metabolism"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-4-1180"},{"key":"e_1_2_1_19_2","first-page":"43","article-title":"Antithyroid agents: structure-activity relationship. II. Interpretation of mechanism of action by complexation of charge transfer","volume":"20","author":"Buxeraud J","year":"1985","journal-title":"European Journal of Medicinal Chemistry"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-3-1683"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-4622(78)85023-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010702)40:13<2486::AID-ANIE2486>3.0.CO;2-N"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10426500590906391"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02708441"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90224-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/14756369309040756","article-title":"Synthesis and the antiperoxidase activity of seleno analogues of the antithyroid drug propylthiouracil","volume":"7","author":"Aboul-Enein H Y","year":"1993","journal-title":"Journal of Enzyme Inhibition"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90569-X"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00095a056"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)00505-G"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja039860g"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja054497u"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-94-5-1286"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1450093"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/a803002b"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","unstructured":"RoyG DasD andMugeshG Bioinorganic chemistry aspects of the inhibition of thyroid hormone biosynthesis by anti-hyperthyroid drugs Inorganica Chimica Acta. In press. http:\/\/dx.doi.org\/10.1016\/j.ica.2006.07.052.","DOI":"10.1016\/j.ica.2006.07.052"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-1-86"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-98-4-1031"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-4-1598"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-1-30"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(86)90636-3"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90957-5"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00364a041"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90194-8"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx00014a003"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00101a007"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000426w"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(95)03552-I"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.7.2871"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1039\/b604060h"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.51.2813"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.45.3375"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.44.3269"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1143\/JPSJ.54.1236"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja012731k"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200390215"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1039\/b503883a"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic0484396"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200501455"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)81352-6"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00216a035"},{"key":"e_1_2_1_62_2","first-page":"445","article-title":"Reaction of imidazole-2-selone derivatives with diiodine - synthesis, structural\nand spectroscopic characterization of the adduct 1,1\u2032-bis(3-methyl-4-imidazolin-2-\nselone)methane bis(diiodine) and of the 1st examples of I-Se-I hypervalent \nseleniumcompounds- 1,3-dimethyl-4-imidazolin-2-ylium diiodo selenanide and 1,2-bis(3-methyl-\n4-imidazolin-2-ylium diiodo selenanide)-ethane bis(dichloromethane)","volume":"124","author":"Bigoli F","year":"1994","journal-title":"Gazzetta Chimica Italiana"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20011119)40:22<4229::AID-ANIE4229>3.0.CO;2-G"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/hc.520040416"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-328X(00)00665-3"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(98)00238-0"}],"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2006\/023214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/BCA\/2006\/23214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:12:51Z","timestamp":1717708371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/BCA\/2006\/23214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/BCA\/2006\/23214"],"URL":"https:\/\/doi.org\/10.1155\/bca\/2006\/23214","archive":["Portico"],"relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"value":"1565-3633","type":"print"},{"value":"1687-479X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"023214"}}