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The formation of\n                    <jats:bold>VL<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>D<\/jats:bold>\n                    involves an oxidation process from V (III) to V (IV) that can occur under conditions similar to those of biological assays. The biological activity of these complexes was explored on six human cancer cell lines exhibiting lower IC50 values in five of them when compared to cisplatin, noteworthy the fact that complex\n                    <jats:bold>VL<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    probed to be more effective against A549 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.07\u2009\u03bcM). At the same time,\n                    <jats:bold>VL<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>1<\/jats:bold>\n                    <\/jats:sub>\n                    showed remarkable activity on HCT\u201015 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20093.14\u2009\u03bcM). Interestingly and in contrast to cisplatin, the vanadium complexes showed little effect on the healthy fibroblast cells. Mechanistic studies of cell death revealed that\n                    <jats:bold>VL<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    selectively induced late\u2010stage apoptosis without promoting necrosis in A549\u2009cells, whereas\n                    <jats:bold>VL<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    did not significantly affect apoptotic or necrotic pathways under the conditions tested. These results were complemented with in silico studies and displacement assays, demonstrating the affinity of the complexes for DNA. The results presented in this work are relevant, as there are few reports of similar V (III) compounds explored as potential anticancer agents.\n                  <\/jats:p>","DOI":"10.1155\/bca\/2823543","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:01Z","timestamp":1781585581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization, and Anticancer Activity of Vanadium (III) Complexes With Pyridyl\u2013Triazole Ligands"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-3358","authenticated-orcid":false,"given":"Yair","family":"Alvarez-Ricardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deissy N.","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Leonardo","family":"Orjuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jim\u00e9nez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-8713","authenticated-orcid":false,"given":"Jorge","family":"Al\u00ed-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-8489","authenticated-orcid":false,"given":"Mario A.","family":"Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Arenaza-Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7984-1819","authenticated-orcid":false,"given":"David","family":"Morales-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9719","authenticated-orcid":false,"given":"John J.","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1608"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.112014"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics10120244"},{"key":"e_1_2_9_5_2","first-page":"1094","article-title":"Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Antileukemic Agent With Matrix Metalloproteinase Inhibitory Activity","volume":"7","author":"Krishna Narla R.","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2022.06.009"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23082013"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126536"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-023-01037-7"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.08.018"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.10.034"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5608"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2017.1286330"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011941"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0197592"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01176"},{"key":"e_1_2_9_17_2","volume-title":"Gaussian 16 Revision D.01","author":"Frisch M. 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