{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:25:32Z","timestamp":1792016732885,"version":"4.4.0"},"reference-count":101,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":153,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative disorder associated with cognitive decline and loss of memory. It is postulated that the generation of reactive oxygen species (ROS) in Fenton\u2010like reaction connected with Cu(II)\/Cu(I) redox cycling of the Cu(II)\u2010a\u03b2 complex can play a key role in the molecular mechanism of neurotoxicity in AD. Semax (Met\u2010Glu\u2010His\u2010Phe\u2010Pro\u2010Gly\u2010Pro) is a synthetic regulatory peptide that possesses a high affinity for Cu(II) ions. The ability of the peptide Semax to inhibit the copper\u2010catalyzed oxidation of a\u03b2 was studied in vitro and discussed. The results indicate that Semax is able to extract Cu(II) from Cu(II)\u2010a\u03b2 species as well as to influence the redox cycling of the Cu(II)\u2010a\u03b2 complex and decrease the level of associated ROS production. Finally, our data suggest that Semax shows cytoprotective properties for SH\u2010SY5Y cells against oxidative stress induced by copper\u2010catalyzed oxidation of the a\u03b2 peptide. This study provides valuable insights into the potential role of Semax in neurodegenerative disorders and into the design of new compounds with therapeutic potential for AD.<\/jats:p>","DOI":"10.1155\/bca\/4226220","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T05:41:22Z","timestamp":1748929282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Semax, a Copper Chelator Peptide, Decreases the Cu(II)\u2010Catalyzed ROS Production and Cytotoxicity of a\u03b2 by Metal Ion Stripping and Redox Silencing"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-2181","authenticated-orcid":false,"given":"Marianna Flora","family":"Tomasello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-5782","authenticated-orcid":false,"given":"Maria Carmela","family":"Di Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-6355","authenticated-orcid":false,"given":"Irina","family":"Naletova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-3321","authenticated-orcid":false,"given":"Michele Francesco Maria","family":"Sciacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-2759","authenticated-orcid":false,"given":"Alessandro","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-1281","authenticated-orcid":false,"given":"Giuseppe","family":"Maccarrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4251-0714","authenticated-orcid":false,"given":"Francesco","family":"Attanasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1039\/b807980n"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1330"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb400080f"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr3000994"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(84)80190-4"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01386.x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300009x"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.02.019"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-006-9033-z"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00092-6"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1mt00008j"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3NJ40999F"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900321"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0MT00073F"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.05.007"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.05.019"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-030409-143539"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2009.05.002"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr040410w"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01543-X"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00138A"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.014"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804562-6.00014-2"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.034"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700111"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp308977s"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011315107"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-129011"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.511345"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202697"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi3006169"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35236B"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.03.013"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305372"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00443K"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi990438f"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206428200"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500238200"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.11.004"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp9095375"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi8011093"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00150E"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0343-3"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00075H"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-23226-5_12"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06938.x"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00483"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2012.05.016"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep17842"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00317-8"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07402.x"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c02693"},{"key":"e_1_2_12_55_2","article-title":"N4-Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-\u03b21\u201316","volume":"24","author":"Zhang W.","year":"2018","journal-title":"Chemistry\u2014A European Journal"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03407"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202003949"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101327"},{"key":"e_1_2_12_59_2","first-page":"420","article-title":"A Nootropic Adrenocorticotropin Analog 4-10-Semax (L5 Years Experience in Its Design and Study)","volume":"47","author":"Asmarin I. P.","year":"1997","journal-title":"Zhurnal vysshei nervnoi deiatelnosti imeni IP Pavlova"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1134\/S1062359018060055"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.4236\/nm.2013.44035"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-006-0328-8"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9432-0"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6769(199609)19:2<115::AID-NRC171>3.0.CO;2-B"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-228"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03324-2"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEULET.2007.02.042"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126179"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893321010040"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes11060681"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2014.09.008"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.08.013"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00707"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.08.014"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0563-x"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M100175200"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/J.1471-4159.2006.03907.X"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6dt01979j"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b00740"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7sc00809k"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.5812\/archneurosci.20078"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5mt00077g"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6mt00299d"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic301244x"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(03)00128-4"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201102746"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803908"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja805940m"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008978501177"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(04)37002-6"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_2_12_92_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2021.07.014","volume-title":"Emerging Roles of Oxidative Stress in Brain Aging and Alzheimer\u2019s Disease","author":"Ionescu-Tucker A.","year":"2021"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25803"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1736-09.2009"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00297"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26247630"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c00480"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2DT03875G"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19620740332"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9mt00045c"},{"key":"e_1_2_12_101_2","unstructured":"TomaselloM. F. GiuffridaA. MaccarroneG. SatrianoC. andAttanasioF. Semax: A Copper Chelator That Influences the Cu(II) Induced Aggregation Ros Production and Cytotoxicity of A\u03b2 by Metal Ion Stripping and Redox Silencing 2018 https:\/\/www.dsctm.cnr.it\/images\/Eventi_img\/Giornata_Dip_2018\/Atti_Conferenza_DSCTM_2018_ISBN978%2088%208080%20339%203.pdf."}],"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bca\/4226220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bca\/4226220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bca\/4226220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:46:39Z","timestamp":1773009999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bca\/4226220"}},"subtitle":[],"editor":[{"given":"Franc","family":"Perdih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/bca\/4226220"],"URL":"https:\/\/doi.org\/10.1155\/bca\/4226220","archive":["Portico"],"relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"value":"1565-3633","type":"print"},{"value":"1687-479X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4226220"}}