{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:48:13Z","timestamp":1784072893599,"version":"3.55.0"},"reference-count":95,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012632","name":"Nazarbayev University","doi-asserted-by":"publisher","award":["20122022FD4112"],"award-info":[{"award-number":["20122022FD4112"]}],"id":[{"id":"10.13039\/501100012632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Bacterial biofilms are a persistent challenge in industrial settings such as water treatment and food processing, contributing to antimicrobial resistance, operational inefficiencies, and environmental burden. Here, we report on the synthesis and multiscale evaluation of hydrogen molybdenum bronze nanosheets (HMB\u2010NSHs) and their silver\u2010decorated nanotube derivatives (Ag\u2013decorated HMB\u2010NTs), produced via an arc discharge method. High\u2010resolution structural analyses revealed crystalline, ultrathin HMB sheets and tubular architectures adorned with uniformly distributed Ag nanoparticles (\u223c3\u20135\u2009nm). While HMB\u2010NSHs were biologically inert, Ag\u2013decorated HMB\u2010NTs demonstrated potent antibacterial effects against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    , inhibiting planktonic growth (75.7%), biofilm formation (77.7%), and biofilm eradication (64.3%) at 25\u2009\u03bcg\/mL. Complementary SEM and fluorescence microscopy visualizations revealed pronounced morphological membrane damage such as wrinkling, roughening, and biofilm reduction signatures absent in control and HMB\u2010treated samples, facilitating metal ion deposition and localized oxidative stress. At the molecular level, multiscale computational modeling, including molecular docking, DFT, QTAIM, RDG, and IGM analyses, provided atomic\u2010resolution insights into dual\u2010site antibacterial action. The Ag and HMB moieties interact favorably with both the cell\u2010wall penicillin\u2010binding protein (PDB ID: 4WO7) and intracellular division regulator FtsZ (PDB ID: 2VAM), forming energetically stable complexes. QTAIM metrics confirmed extensive van der Waals and hydrogen bonding networks with 4WO7, whereas RDG and IGM surfaces visualized dense noncovalent contact regions. Ag\u2013FtsZ interactions, though weaker, suggest possible disruption of cell cycle machinery upon internalization. These findings establish Ag\u2010decorated HMB\u2010NTs as a dual\u2010function nanomaterial: HMB scaffolds promote surface adhesion and stability, whereas Ag enables membrane destabilization and intracellular disruption. Together, these processes highlight membrane damage and protein interference as the primary antibacterial mechanisms, underscoring their potential as a next\u2010generation antibacterial platform, particularly against biofilm\u2010forming and industrially relevant bacteria such as\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/bca\/9270509","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:01:08Z","timestamp":1773014468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ag\u2010Decorated Hydrogen Molybdenum Bronze Nanotubes as Dual\u2010Action Agents Against\n                    <i>Bacillus subtilis<\/i>\n                    : Experimental and Theoretical Insights Into Membrane Damage and Protein Interference"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0054-5785","authenticated-orcid":false,"given":"Shabnam","family":"Yavari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6339-5272","authenticated-orcid":false,"given":"Neda","family":"Eghtesadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-3866","authenticated-orcid":false,"given":"Kayode","family":"Olaifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-0743","authenticated-orcid":false,"given":"Darya","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-0259","authenticated-orcid":false,"given":"Amir H.","family":"Montazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-8584","authenticated-orcid":false,"given":"Reza","family":"Rasuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-6915","authenticated-orcid":false,"given":"Ebrahim","family":"Nemati-Kande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3770-593X","authenticated-orcid":false,"given":"Forough","family":"Pakzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7093-9887","authenticated-orcid":false,"given":"Sorour","family":"Faramarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-7191","authenticated-orcid":false,"given":"Mehdi","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.202400356"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.202400207"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41742-017-0006-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2023.100171"},{"key":"e_1_2_11_5_2","volume-title":"What is Antimicrobial Resistance and Why is it a Problem?","author":"McLean S.","year":"2023"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101875"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201908289"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101880"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s121956"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra07119k"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2025.3567407"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano13081327"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0508542"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.46.8.2668-2670.2002"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205923"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2008.09.002"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-23401-1"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92864-2"},{"key":"e_1_2_11_20_2","article-title":"Antimicrobial Efficacy of Ag-Doped ZnO Nanocomposite Against Bacillus Subtilis","author":"Gurjar K. C.","year":"2023","journal-title":"Materials Today: Proceedings"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10876-021-02164-8"},{"key":"e_1_2_11_22_2","article-title":"Facile Construction of Silver Decorated on Carbon Nanotube in Natural Rubber and Polyethylene Blend for Antibacterial Activity","author":"Nguyen T. T.","year":"2023","journal-title":"VNU Journal of Science: Natural Sciences and Technology"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511574689"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18115731"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.03.013"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007486"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1149\/2162-8777\/ac5a6f"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtener.2022.101154"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/catal8070294"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202203964"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0968-0004(02)02107-2"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4596(79)90193-2"},{"key":"e_1_2_11_33_2","volume-title":"Low-Dimensional Electronic Properties of Molybdenum Bronzes and Oxides","author":"Schlenker C.","year":"2012"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/13642818508240627"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00840"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/jssc.2001.9450"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ad9def"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-1352(199601)9:1<1::aid-jmr241>3.0.co;2-6"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002140050353"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/8.2.127"},{"key":"e_1_2_11_42_2","volume-title":"Gaussian Basis Sets for Molecular Calculations","author":"Huzinaga S.","year":"2012"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-017-0691-y"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00310a007"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-1280(92)87061-4"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp102748b"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26812"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja100936w"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2013.10.026"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2020.119818"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202630"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1670-8"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.201300896"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2019.00188"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2010.03.002"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1143\/jjap.27.1798"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2017.12.012"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2016.11.225"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2018.09.003"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/solr.201900480"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensm.2017.11.018"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132380"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020165"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123528"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.7417\/CT.2023.2498"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16047-z"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-020-01744-x"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2020.10.008"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-017-0308-z"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01831"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s246764"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1049\/mnl.2017.0648"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020449"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.2.283"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.10.012"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s355131"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.855136"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s258319"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072375"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano12132316"},{"key":"e_1_2_11_81_2","first-page":"190","article-title":"The Effects of Different Concentrations of Sliver Nanoparticles on the Kidneys of Male Albino Mice","volume":"50","author":"Zamil R.","year":"2018","journal-title":"American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano15030202"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsagscitech.4c00624"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-013-0085-6"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14100509"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/app112210695"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2019.11.019"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.112212"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn102941b"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054801"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137202"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano10020292"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c00417"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.622910"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.08.056"}],"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bca\/9270509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bca\/9270509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bca\/9270509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:01:11Z","timestamp":1773014471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bca\/9270509"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Ciccarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bca\/9270509"],"URL":"https:\/\/doi.org\/10.1155\/bca\/9270509","archive":["Portico"],"relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"value":"1565-3633","type":"print"},{"value":"1687-479X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9270509"}}