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In this study, we investigated primaquine (PQ), a clinically used antimalarial drug, and PQ\u2013lactobionic acid conjugate (LAPQ), a newly synthesized and characterized derivative obtained through conjugation with lactobionic acid, designed to improve physicochemical and biological properties. Both compounds were evaluated for their copper\u2010coordination ability, antioxidant properties, interaction with amyloid\u2010\u03b2 (A\u03b2), and capacity to modulate reactive oxygen species (ROS)\u2010induced cellular damage. As a complementary biological line of investigation, their in vitro antiproliferative activity in the presence and absence of copper was also evaluated. The compounds directly interact with A\u03b2 as demonstrated by surface plasmon resonance (SPR) studies. Biological studies revealed marked differences between the two molecules. PQ displayed intrinsic cytotoxicity, whereas LAPQ exhibited enhanced aqueous solubility and substantially reduced antiproliferative activity under the tested conditions, highlighting the impact of sugar conjugation. In cellular oxidative stress models, LAPQ showed a protective effect, preserving cell viability under ROS\u2010generating conditions. In summary, by interacting with A\u03b2 and exhibiting antioxidant activity, two properties relevant to several neurodegenerative and peripheral aggregation\u2010related disorders, our novel compound LAPQ may provide a potential starting point for the development of therapies targeting A\u03b2\u2013associated disorders.<\/jats:p>","DOI":"10.1155\/bca\/9997326","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:15:55Z","timestamp":1789020955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactobionic Acid as a Biocompatibility Switch: Physicochemical and Biological Characterization of Copper(II)\u2013Primaquine 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