{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:19:20Z","timestamp":1758478760302,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["N 04-03-33116","N 03-03-32938"],"award-info":[{"award-number":["N 04-03-33116","N 03-03-32938"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["N 04-03-33116","N 03-03-32938"],"award-info":[{"award-number":["N 04-03-33116","N 03-03-32938"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>The study of inorganic tin (SnCl<jats:sub>2<\/jats:sub>, SnCl<jats:sub>4<\/jats:sub>) and methyltin compounds (MeSnCl<jats:sub>3<\/jats:sub>, Me<jats:sub>2<\/jats:sub>SnCI<jats:sub>2<\/jats:sub>, Me<jats:sub>3<\/jats:sub>SnCl)\neffects on the enzymatic activity of alcohol dehydrogenase (ADH) in the reaction of ethanol oxidation has\nbeen carried out. The experimental results of the study show that inorganic tin and methyltin substances\ninduce slight inhibition of the catalytic activity of horse liver alcohol dehydrogenase (HLADH), unable to be\nimproved during pre\u2010incubation with the enzyme. The conditions for carrying out the kinetic investigation of\nthe mentioned phenomenon were optimized and as it turned out the mechanism of methyltin trichloride\naction, as the most effective methyltin inhibitor, is more complex than the proposed interaction of the metal\natom with SH\u2010groups of the enzyme protein. It was demonstrated that the tin compounds act in the same\nmanner as methylmercury compounds and might serve as oxidative agents towards the co\u2010enzyme NADH.\nKinetic data on MeSnCl<jats:sub>3<\/jats:sub> were calculated. Data acquired on NAD\u2010dependent ADH from horse liver and those\nregarding NAD\u2010dependent LDH from sturgeon liver were compared.<\/jats:p>","DOI":"10.1155\/bca.2005.191","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T12:46:52Z","timestamp":1173185212000},"page":"191-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of Horse Liver Alcohol Dehydrogenase byMethyltin Compounds"],"prefix":"10.1155","volume":"3","author":[{"given":"Pavel V.","family":"Bychkov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana N.","family":"Shekhovtsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena R.","family":"Milaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1]]},"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2005\/636820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/BCA.2005.191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:29:37Z","timestamp":1722331777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/BCA.2005.191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/BCA.2005.191"],"URL":"https:\/\/doi.org\/10.1155\/bca.2005.191","archive":["Portico"],"relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"type":"print","value":"1565-3633"},{"type":"electronic","value":"1687-479X"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}